3-[trans-2-(2,6-difluorophenyl)vinyl]-5-(2-methoxy-(1S)-methyl-ethoxy)-benzoic acid

Base Information

Chemical Name:3-[trans-2-(2,6-difluorophenyl)vinyl]-5-(2-methoxy-(1S)-methyl-ethoxy)-benzoic acid
CAS No.:1282521-26-9
Molecular Formula:C₁₉H₁₈F₂O₄
Molecular Weight:348.346
Hs Code.:

Synonyms:3-[trans-2-(2,6-difluorophenyl)vinyl]-5-(2-methoxy-(1S)-methyl-ethoxy)-benzoic acid

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Chemical Property of 3-[trans-2-(2,6-difluorophenyl)vinyl]-5-(2-methoxy-(1S)-methyl-ethoxy)-benzoic acid

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Technology Process of 3-[trans-2-(2,6-difluorophenyl)vinyl]-5-(2-methoxy-(1S)-methyl-ethoxy)-benzoic acid

There total 6 articles about 3-[trans-2-(2,6-difluorophenyl)vinyl]-5-(2-methoxy-(1S)-methyl-ethoxy)-benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 15.0%

: 437-81-0
2,6-difluorobenzaldehyde

: 1282521-09-8
3-[(phosphonic acid diethyl ester)-methyl]-5-(2-methoxy-(1S)-methyl-ethoxy)-benzoic acid methyl ester

: 1282521-26-9
3-[trans-2-(2,6-difluorophenyl)vinyl]-5-(2-methoxy-(1S)-methyl-ethoxy)-benzoic acid

Guidance literature:: With potassium hydroxide; 18-crown-6 ether; In dichloromethane; at 20 ℃; for 16h;

Reference yield:

: 13036-02-7
Dimethyl 5-hydroxyisophthalate

: 1282521-26-9
3-[trans-2-(2,6-difluorophenyl)vinyl]-5-(2-methoxy-(1S)-methyl-ethoxy)-benzoic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 12 h / 0 - 20 °C

2.1: potassium hydroxide; methanol / 12 h / 100 °C

3.1: borane-THF / tetrahydrofuran / 12 h / 0 - 20 °C

3.2: 3 h / 0 °C

4.1: tribromide phosphate / tetrahydrofuran / 12 h / 0 - 20 °C

5.1: 3 h / 160 °C

6.1: potassium hydroxide / 18-crown-6 ether / dichloromethane / 16 h / 20 °C

With methanol; borane-THF; di-isopropyl azodicarboxylate; tribromide phosphate; triphenylphosphine; potassium hydroxide; 18-crown-6 ether; In tetrahydrofuran; dichloromethane;

Reference yield:

: 1282520-90-4
5-(2-methoxy-(1S)-methyl-ethoxy)isophthalic acid monomethyl ester

: 1282521-26-9
3-[trans-2-(2,6-difluorophenyl)vinyl]-5-(2-methoxy-(1S)-methyl-ethoxy)-benzoic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: borane-THF / tetrahydrofuran / 12 h / 0 - 20 °C

1.2: 3 h / 0 °C

2.1: tribromo phosphate / tetrahydrofuran / 12 h / 0 - 20 °C

3.1: 3 h / 160 °C

4.1: potassium hydroxide / 18-crown-6 ether / dichloromethane / 16 h / 20 °C

With borane-THF; tribromo phosphate; potassium hydroxide; 18-crown-6 ether; In tetrahydrofuran; dichloromethane;