His-[2-amino-iso-butyryl]-Glu-Gly-Thr-[(L)-α-methyl-(2-fluorophenyl)alanyl]-Thr-Ser-Asp-[2-amino-3-(2'-ethyl-4'-methoxy-biphenyl-4-yl)propanoyl]-[2-amino-3-(2'-methyl-biphenyl-4-yl)propanoyl]-NH2

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Chemical Name:His-[2-amino-iso-butyryl]-Glu-Gly-Thr-[(L)-α-methyl-(2-fluorophenyl)alanyl]-Thr-Ser-Asp-[2-amino-3-(2'-ethyl-4'-methoxy-biphenyl-4-yl)propanoyl]-[2-amino-3-(2'-methyl-biphenyl-4-yl)propanoyl]-NH2
CAS No.:516518-88-0
Molecular Formula:C₇₆H₉₅FN₁₄O₁₉
Molecular Weight:1527.67
Hs Code.:

His-[2-amino-iso-butyryl]-Glu-Gly-Thr-[(L)-α-methyl-(2-fluorophenyl)alanyl]-Thr-Ser-Asp-[2-amino-3-(2'-ethyl-4'-methoxy-biphenyl-4-yl)propanoyl]-[2-amino-3-(2'-methyl-biphenyl-4-yl)propanoyl]-NH2

Synonyms:His-[2-amino-iso-butyryl]-Glu-Gly-Thr-[(L)-α-methyl-(2-fluorophenyl)alanyl]-Thr-Ser-Asp-[2-amino-3-(2'-ethyl-4'-methoxy-biphenyl-4-yl)propanoyl]-[2-amino-3-(2'-methyl-biphenyl-4-yl)propanoyl]-NH2

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Chemical Property of His-[2-amino-iso-butyryl]-Glu-Gly-Thr-[(L)-α-methyl-(2-fluorophenyl)alanyl]-Thr-Ser-Asp-[2-amino-3-(2'-ethyl-4'-methoxy-biphenyl-4-yl)propanoyl]-[2-amino-3-(2'-methyl-biphenyl-4-yl)propanoyl]-NH2

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Technology Process of His-[2-amino-iso-butyryl]-Glu-Gly-Thr-[(L)-α-methyl-(2-fluorophenyl)alanyl]-Thr-Ser-Asp-[2-amino-3-(2'-ethyl-4'-methoxy-biphenyl-4-yl)propanoyl]-[2-amino-3-(2'-methyl-biphenyl-4-yl)propanoyl]-NH2

There total 1 articles about His-[2-amino-iso-butyryl]-Glu-Gly-Thr-[(L)-α-methyl-(2-fluorophenyl)alanyl]-Thr-Ser-Asp-[2-amino-3-(2'-ethyl-4'-methoxy-biphenyl-4-yl)propanoyl]-[2-amino-3-(2'-methyl-biphenyl-4-yl)propanoyl]-NH2 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1172127-44-4
N-Fmoc-(S)-2-fluoro-α-methylphenylalanine

: (S)-2-((9H-fluoren-9-yloxy)carbonylamino)-3-(2'-ethyl-4'-methoxy-biphenyl-4-yl)propanoic acid

: C₃₄H₃₆N₃O₅Pol

: 29022-11-5
N-(fluoren-9-ylmethoxycarbonyl)glycine

: 71989-33-8
Fmoc-Ser(tBu)-OH

: 71989-14-5
Fmoc-(tBu)Asp-OH

: 71989-18-9
Fmoc-Glu(OtBu)-OH

: 71989-35-0,138797-71-4
Fmoc-Thr(tBu)-OH

: 109425-51-6
Fmoc-His(Trt)-OH

: 94744-50-0
N-[(9H-fluoren-9-ylmethoxy)carbonyl]-α-aminoisobutyric acid

: 516518-88-0
His-[2-amino-iso-butyryl]-Glu-Gly-Thr-[(L)-α-methyl-(2-fluorophenyl)alanyl]-Thr-Ser-Asp-[2-amino-3-(2'-ethyl-4'-methoxy-biphenyl-4-yl)propanoyl]-[2-amino-3-(2'-methyl-biphenyl-4-yl)propanoyl]-NH2

Guidance literature:: (S)-2-((9H-fluoren-9-yloxy)carbonylamino)-3-(2'-ethyl-4'-methoxy-biphenyl-4-yl)propanoic acid; C₃₄H₃₆N₃O₅Pol; With 1-hydroxy-7-aza-benzotriazole; dicyclohexyl-carbodiimide; In 1-methyl-pyrrolidin-2-one; Automated synthesizer; solid phase reaction;

With piperidine; In N,N-dimethyl-formamide; for 0.35h; Automated synthesizer; solid phase reaction;

N-Fmoc-(S)-2-fluoro-α-methylphenylalanine; N-(fluoren-9-ylmethoxycarbonyl)glycine; Fmoc-Ser(tBu)-OH; Fmoc-(tBu)Asp-OH; Fmoc-Glu(OtBu)-OH; Fmoc-Thr(tBu)-OH; Fmoc-His(Trt)-OH; N-[(9H-fluoren-9-ylmethoxy)carbonyl]-α-aminoisobutyric acid; Further stages;
DOI:10.1021/jm900752a