methyl 4-{3-[2-(dimethylaminocarbonyl)ethyl]-4-[6-(4-methoxyphenyl)-(5E)-hexenyloxy]phenylaminocarbonyl}butanoate

Base Information

Chemical Name:methyl 4-{3-[2-(dimethylaminocarbonyl)ethyl]-4-[6-(4-methoxyphenyl)-(5E)-hexenyloxy]phenylaminocarbonyl}butanoate
CAS No.:197707-80-5
Molecular Formula:C₃₀H₄₀N₂O₆
Molecular Weight:524.657
Hs Code.:

Synonyms:methyl 4-{3-[2-(dimethylaminocarbonyl)ethyl]-4-[6-(4-methoxyphenyl)-(5E)-hexenyloxy]phenylaminocarbonyl}butanoate

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Chemical Property of methyl 4-{3-[2-(dimethylaminocarbonyl)ethyl]-4-[6-(4-methoxyphenyl)-(5E)-hexenyloxy]phenylaminocarbonyl}butanoate

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Technology Process of methyl 4-{3-[2-(dimethylaminocarbonyl)ethyl]-4-[6-(4-methoxyphenyl)-(5E)-hexenyloxy]phenylaminocarbonyl}butanoate

There total 14 articles about methyl 4-{3-[2-(dimethylaminocarbonyl)ethyl]-4-[6-(4-methoxyphenyl)-(5E)-hexenyloxy]phenylaminocarbonyl}butanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 502-44-3,24980-41-4,80137-66-2
hexahydro-2H-oxepin-2-one

: 197707-80-5
methyl 4-{3-[2-(dimethylaminocarbonyl)ethyl]-4-[6-(4-methoxyphenyl)-(5E)-hexenyloxy]phenylaminocarbonyl}butanoate

Guidance literature:: Multi-step reaction with 10 steps

1: conc. sulfuric acid / 1 h / Heating

2: AlCl₃ / 1,2-dichloro-ethane / 2.5 h / 15 °C

3: 5N aq. NaOH / methanol / 1 h / 25 °C

4: NaBH₄ / methanol / 1 h / 25 - 65 °C

5: 73 percent / KCl / dimethylsulfoxide / 4 h / 170 °C

6: 92 percent / triethylamine / CH₂Cl₂ / 1 h

7: 1.) NaH / 1.) DMF, a) from 0 deg C - 25 deg C, b) 25 deg C, 30 min, 2.) DMF, 60 deg C, 2 h

8: HCOOH / 0.5 h / 25 °C

9: Et₃N / tetrahydrofuran / 0.08 h / -10 °C

10: tetrahydrofuran; H₂O / 0.08 h / 25 °C

With sodium hydroxide; sodium tetrahydroborate; aluminium trichloride; formic acid; sulfuric acid; potassium chloride; sodium hydride; triethylamine; In tetrahydrofuran; methanol; dichloromethane; water; dimethyl sulfoxide; 1,2-dichloro-ethane;
DOI:10.1016/S0968-0896(97)00089-8

Reference yield:

: 128577-60-6
(5E)-6-(4-Methoxyphenyl)-5-hexen-1-ol

: 197707-80-5
methyl 4-{3-[2-(dimethylaminocarbonyl)ethyl]-4-[6-(4-methoxyphenyl)-(5E)-hexenyloxy]phenylaminocarbonyl}butanoate

Guidance literature:: Multi-step reaction with 5 steps

1: 92 percent / triethylamine / CH₂Cl₂ / 1 h

2: 1.) NaH / 1.) DMF, a) from 0 deg C - 25 deg C, b) 25 deg C, 30 min, 2.) DMF, 60 deg C, 2 h

3: HCOOH / 0.5 h / 25 °C

4: Et₃N / tetrahydrofuran / 0.08 h / -10 °C

5: tetrahydrofuran; H₂O / 0.08 h / 25 °C

With formic acid; sodium hydride; triethylamine; In tetrahydrofuran; dichloromethane; water;
DOI:10.1016/S0968-0896(97)00089-8

Reference yield:

: 17814-85-6
(4-carboxybutyl)triphenylphosphonium bromide

: 197707-80-5
methyl 4-{3-[2-(dimethylaminocarbonyl)ethyl]-4-[6-(4-methoxyphenyl)-(5E)-hexenyloxy]phenylaminocarbonyl}butanoate

Guidance literature:: Multi-step reaction with 8 steps

1: 1.) t-BuOK / 1.) toluene, reflux, 30 min, 2.) toluene, 100 deg C, 10 min

2: conc. sulfuric acid / 1 h / 80 °C

3: 68 percent / LiAlH₄ / tetrahydrofuran / 0.5 h / 25 °C

4: 92 percent / triethylamine / CH₂Cl₂ / 1 h

5: 1.) NaH / 1.) DMF, a) from 0 deg C - 25 deg C, b) 25 deg C, 30 min, 2.) DMF, 60 deg C, 2 h

6: HCOOH / 0.5 h / 25 °C

7: Et₃N / tetrahydrofuran / 0.08 h / -10 °C

8: tetrahydrofuran; H₂O / 0.08 h / 25 °C

With lithium aluminium tetrahydride; formic acid; sulfuric acid; potassium tert-butylate; sodium hydride; triethylamine; In tetrahydrofuran; dichloromethane; water;
DOI:10.1016/S0968-0896(97)00089-8