O-2,3-anhydro-1-<5-O-(monomethoxytrityl)-2-deoxy-2-fluoro-β-D-lyxofuranosyl>thymine

Base Information

Chemical Name:O-2,3-anhydro-1-<5-O-(monomethoxytrityl)-2-deoxy-2-fluoro-β-D-lyxofuranosyl>thymine
CAS No.:124424-31-3
Molecular Formula:C₃₀H₂₇FN₂O₅
Molecular Weight:514.553
Hs Code.:

Synonyms:O-2,3-anhydro-1-<5-O-(monomethoxytrityl)-2-deoxy-2-fluoro-β-D-lyxofuranosyl>thymine

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Chemical Property of O-2,3-anhydro-1-<5-O-(monomethoxytrityl)-2-deoxy-2-fluoro-β-D-lyxofuranosyl>thymine

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Technology Process of O-2,3-anhydro-1-<5-O-(monomethoxytrityl)-2-deoxy-2-fluoro-β-D-lyxofuranosyl>thymine

There total 10 articles about O-2,3-anhydro-1-<5-O-(monomethoxytrityl)-2-deoxy-2-fluoro-β-D-lyxofuranosyl>thymine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.6%

: 124424-30-2
1-<3-O-(methylsulfonyl)-5-O-(monomethoxytrityl)-2-deoxy-2-fluoro-β-D-arabinofuranosyl>thymine

: 124424-31-3
O-2,3-anhydro-1-<5-O-(monomethoxytrityl)-2-deoxy-2-fluoro-β-D-lyxofuranosyl>thymine

Guidance literature:: With sodium hydroxide; In ethanol; for 2h; Heating;
DOI:10.1021/jm00170a017

Reference yield:

: 22224-41-5
1,3,5-tri-O-benzoyl-α-D-ribofuranoside

: 124424-31-3
O-2,3-anhydro-1-<5-O-(monomethoxytrityl)-2-deoxy-2-fluoro-β-D-lyxofuranosyl>thymine

Guidance literature:: Multi-step reaction with 6 steps

1.1: 83 percent / [bis(2-methoxyethyl)amino]sulfur trifluoride / CH₂Cl₂ / 50 °C

2.1: 90 percent / HBr / CH₂Cl₂ / 24 h / 20 °C

3.1: CCl₄ / 72 h / 77 °C

3.2: NH₄OH / methanol / 24 h / 20 °C

4.1: 87 percent / pyridine

5.1: pyridine

6.1: triethylamine / ethanol / 16 h / Heating

With pyridine; hydrogen bromide; triethylamine; (bis-(2-methoxyethyl)amino)sulfur trufluoride; In tetrachloromethane; ethanol; dichloromethane;
DOI:10.1081/NCN-120022961

Reference yield:

: 22423-26-3
O-2,2'-cyclo-5-methyluridine

: 124424-31-3
O²,3'-anhydro-1-(2-deoxy-2-fluoro-5-O-monomethoxytrityl-β-D-xylofuranosyl)thymine

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) pyridine, 2.) NaOH / 1.) 60 deg C, 18 h, 2.) dioxane-methanol-water, room temperature overnight, reflux 30 min

3: trifluoromethanesulfonic anhydride, pyridine, 2.) NaOH / 1.) dichloromethane, 0 deg C, 1 h, 2.) dioxane-water, room temperature, 3 h

With pyridine; sodium hydroxide; trifluoromethanesulfonic acid anhydride;