6-amidino-2-naphthyl 4-aminobenzoate dimethanesulfonate

Base Information

• Chemical Name: 6-amidino-2-naphthyl 4-aminobenzoate dimethanesulfonate
• CAS No.: 82955-98-4
• Molecular Formula: 2CH₄O₃S*C₁₈H₁₅N₃O₂
• Molecular Weight: 497.55
• Mol file: 82955-98-4.mol

Synonyms:6-amidino-2-naphthyl 4-aminobenzoate dimethanesulfonate

Chemical Property of 6-amidino-2-naphthyl 4-aminobenzoate dimethanesulfonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of 6-amidino-2-naphthyl 4-aminobenzoate dimethanesulfonate

There total 7 articles about 6-amidino-2-naphthyl 4-aminobenzoate dimethanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

methanesulfonic acid (75-75-2,98527-29-8) + 4-Acetylamino-benzoic acid 6-carbamimidoyl-naphthalen-2-yl ester; compound with methanesulfonic acid (82956-08-9) → 6-amidino-2-naphthyl 4-aminobenzoate dimethanesulfonate (82955-98-4)

Guidance literature:

With hydrogen; palladium on activated charcoal; In N,N-dimethyl-formamide; for 2h; Ambient temperature;

DOI:10.1248/cpb.33.1458

Reference yield:

6-Amidino-2-naphthol (58200-88-7) → 6-amidino-2-naphthyl 4-aminobenzoate dimethanesulfonate (82955-98-4)

Guidance literature:

Multi-step reaction with 3 steps

1: methanol

2: 1.) dicyclohexylcarbodiimide (DCC) / 1.) pyridine, room temp.; 2.) H₂O

3: 95 percent / H₂ / Pd-C (10percent) / dimethylformamide / 2 h / Ambient temperature

With hydrogen; dicyclohexyl-carbodiimide; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide;

DOI:10.1248/cpb.33.1458

Reference yield:

6-bromo-naphthalen-2-ol (15231-91-1) → 6-amidino-2-naphthyl 4-aminobenzoate dimethanesulfonate (82955-98-4)

Guidance literature:

Multi-step reaction with 6 steps

1: 83 percent / CuCN / dimethylformamide / 3 h / 160 - 170 °C

2: HCl / Ambient temperature

3: NH₃ / methanol / 3 h / 50 °C

4: methanol

5: 1.) dicyclohexylcarbodiimide (DCC) / 1.) pyridine, room temp.; 2.) H₂O

6: 95 percent / H₂ / Pd-C (10percent) / dimethylformamide / 2 h / Ambient temperature

With hydrogenchloride; ammonia; hydrogen; dicyclohexyl-carbodiimide; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide;

DOI:10.1248/cpb.33.1458

upstream raw materials:

methanesulfonic acid

4-Acetylamino-benzoic acid 6-carbamimidoyl-naphthalen-2-yl ester; compound with methanesulfonic acid

6-bromo-naphthalen-2-ol

6-cyano-2-naphthol

Refernces

• 1、 -. "AMIDINE COMPOUND". . . Retrieved 2008/06/13.