5-bromo-3-[3-(2-fluoro-4,5-dimethoxyphenyl)-acryloyl]-2-hydroxybenzoic acid

Base Information

Chemical Name:5-bromo-3-[3-(2-fluoro-4,5-dimethoxyphenyl)-acryloyl]-2-hydroxybenzoic acid
CAS No.:1289079-95-3
Molecular Formula:C₁₈H₁₄BrFO₆
Molecular Weight:425.208
Hs Code.:

Synonyms:5-bromo-3-[3-(2-fluoro-4,5-dimethoxyphenyl)-acryloyl]-2-hydroxybenzoic acid

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Chemical Property of 5-bromo-3-[3-(2-fluoro-4,5-dimethoxyphenyl)-acryloyl]-2-hydroxybenzoic acid

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Technology Process of 5-bromo-3-[3-(2-fluoro-4,5-dimethoxyphenyl)-acryloyl]-2-hydroxybenzoic acid

There total 3 articles about 5-bromo-3-[3-(2-fluoro-4,5-dimethoxyphenyl)-acryloyl]-2-hydroxybenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 32.0%

: 71924-62-4
2-fluoro-4,5-dimethoxybenzaldehyde

: 1760-84-5
2-hydroxy-3-acetyl-5-bromobenzoic acid

: 1289079-95-3
5-bromo-3-[3-(2-fluoro-4,5-dimethoxyphenyl)-acryloyl]-2-hydroxybenzoic acid

Guidance literature:: 2-fluoro-4,5-dimethoxybenzaldehyde; 2-hydroxy-3-acetyl-5-bromobenzoic acid; With sodium hydroxide; In ethanol; water; at 20 ℃;

With hydrogenchloride; In ethanol; water; pH=4;
DOI:10.1016/j.bmc.2011.01.047

Reference yield:

: 89-55-4
5-bromosalicyclic acid

: 1289079-95-3
5-bromo-3-[3-(2-fluoro-4,5-dimethoxyphenyl)-acryloyl]-2-hydroxybenzoic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: sulfuric acid / 0.33 h

2.1: aluminum (III) chloride / 3 h / 160 °C / Neat (no solvent)

3.1: sodium hydroxide / ethanol; water / 20 °C

3.2: pH 4

With aluminum (III) chloride; sulfuric acid; sodium hydroxide; In ethanol; water; 2.1: Fries rearrangement / 3.1: Claisen Schmidt condensation;
DOI:10.1016/j.bmc.2011.01.047

Reference yield:

: 1503-53-3
2-acetyloxy-5-bromobenzoic acid

: 1289079-95-3
5-bromo-3-[3-(2-fluoro-4,5-dimethoxyphenyl)-acryloyl]-2-hydroxybenzoic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: aluminum (III) chloride / 3 h / 160 °C / Neat (no solvent)

2.1: sodium hydroxide / ethanol; water / 20 °C

2.2: pH 4

With aluminum (III) chloride; sodium hydroxide; In ethanol; water; 1.1: Fries rearrangement / 2.1: Claisen Schmidt condensation;
DOI:10.1016/j.bmc.2011.01.047