Ethanone, 1-(2-aminophenyl)-2,2,2-trifluoro- (9CI)

Base Information

• Chemical Name: Ethanone, 1-(2-aminophenyl)-2,2,2-trifluoro- (9CI)
• CAS No.: 351002-89-6
• Molecular Formula: C8H6 F3 N O
• Molecular Weight: 189.137
• Hs Code.: 2922399090
• Mol file: 351002-89-6.mol

Synonyms:1-(2-Aminophenyl)-2,2,2-trifluoroethanone;2-(Trifluoroacetyl)aniline

Chemical Property of Ethanone, 1-(2-aminophenyl)-2,2,2-trifluoro- (9CI)

Chemical Property:

• PSA: 43.09000
• LogP: 2.59500

Purity/Quality:

97% ^*data from raw suppliers

1-(2-aminophenyl)-2,2,2-trifluoroethanone 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Ethanone, 1-(2-aminophenyl)-2,2,2-trifluoro- (9CI)

There total 16 articles about Ethanone, 1-(2-aminophenyl)-2,2,2-trifluoro- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

1,1,1-trifluoro-2-hydroxy-2-(2-aminophenyl)ethane (205756-49-6) → 1-(2-amino-5-phenyl)-2,2,2-trifluoroethanone (351002-89-6)

Guidance literature:

With 1,10-Phenanthroline; diethyl hydrazodicarboxylate; oxygen; potassium carbonate; copper(l) chloride; In toluene; at 90 ℃; for 1h;

DOI:10.1021/jo900573v

Reference yield: 75.0%

3-(trifluoromethyl)-2,1-benzisoxazole → 1-(2-amino-5-phenyl)-2,2,2-trifluoroethanone (351002-89-6)

Guidance literature:

With 5%-palladium/activated carbon; hydrogen; In ethyl acetate; for 12h;

DOI:10.1007/s11172-014-0733-1

Reference yield: 58.0%

N-(2-bromophenyl)-2,2-dimethylpropanamide (65854-92-4) + trifluoroacetic anhydride (407-25-0) → 1-(2-amino-5-phenyl)-2,2,2-trifluoroethanone (351002-89-6)

Guidance literature:

N-(2-bromophenyl)-2,2-dimethylpropanamide; With n-butyllithium; In tetrahydrofuran; hexane; at -30 - 20 ℃; for 1h; Inert atmosphere;

trifluoroacetic anhydride; In tetrahydrofuran; hexane; at -30 - 20 ℃; for 16h; Inert atmosphere;

With hydrogenchloride; In tetrahydrofuran; water; at 80 ℃; for 16h; Inert atmosphere;

upstream raw materials:

1,1,1-trifluoro-2-hydroxy-2-(2-aminophenyl)ethane

1-(2-amino-5-chloro-phenyl)-2,2,2-trifluoro-ethanone

N-[2-(trifluoroacetyl)phenyl]-2,2-dimethylpropionamide

1-(2-chlorophenyl)-2,2,2-trifluoroethanol

Downstream raw materials:

C₁₆H₁₈F₃NO₂S₂

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