2-PHENYL-4-(TRIFLUOROMETHYL)QUINOLINE

Base Information

• Chemical Name: 2-PHENYL-4-(TRIFLUOROMETHYL)QUINOLINE
• CAS No.: 64196-43-6
• Molecular Formula: C16H10F3N
• Molecular Weight: 273.257
• Hs Code.: 2933499090
• Mol file: 64196-43-6.mol

Synonyms:2-Phenyl-4-trifluoromethyl-quinoline;2-Phenyl-4-(trifluoromethyl)quinoline;2-Phenyl-4-trifluormethylchinolin;2-phenyl-4-trifluoromethylquinoline;

Chemical Property of 2-PHENYL-4-(TRIFLUOROMETHYL)QUINOLINE

Chemical Property:

• Melting Point: 37.2 - 39 °C
• PSA: 12.89000
• LogP: 4.92060

Purity/Quality:

98%min ^*data from raw suppliers

2-Phenyl-4-(trifluoromethyl)quinoline 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of 2-PHENYL-4-(TRIFLUOROMETHYL)QUINOLINE

There total 17 articles about 2-PHENYL-4-(TRIFLUOROMETHYL)QUINOLINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

2-phenyl-1-tosyl-4-(trifluoromethyl)-1,2-dihydroquinoline → 2-phenyl-4-(trifluoromethyl)quinoline (64196-43-6)

Guidance literature:

With magnesium; In methanol; at 80 ℃; Inert atmosphere;

DOI:10.1021/acs.orglett.9b00330

Reference yield: 76.0%

2-phenylquinoline-4-carbonyl fluoride + (trifluoromethyl)triethylsilane (120120-26-5) → 2-phenyl-4-(trifluoromethyl)quinoline (64196-43-6)

Guidance literature:

With potassium phosphate; [PdCl(cinnamyl)]₂; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In toluene; at 170 ℃; for 16h;

DOI:10.1002/cssc.201900408

Reference yield: 74.0%

acetophenone (98-86-2) + 1,1,1-trifluoro-2-hydroxy-2-(2-aminophenyl)ethane (205756-49-6) → 2-phenyl-4-(trifluoromethyl)quinoline (64196-43-6)

Guidance literature:

With dimethyl sulfoxide; potassium hydroxide; at 80 ℃; for 7h;

DOI:10.1002/ejoc.202000365

upstream raw materials:

1-Phenyl-4,4,4-trifluorobutane-1,3-dione

aniline

phenylacetylene

1-(2-amino-5-phenyl)-2,2,2-trifluoroethanone

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