(2S,4S)-2-[N-(benzyloxycarbonyl)-N-methylamino]-5,5-dichloro-4-methylpentanoic acid methyl ester

Base Information

Chemical Name:(2S,4S)-2-[N-(benzyloxycarbonyl)-N-methylamino]-5,5-dichloro-4-methylpentanoic acid methyl ester
CAS No.:916675-82-6
Molecular Formula:C₁₆H₂₁Cl₂NO₄
Molecular Weight:362.253
Hs Code.:

Synonyms:(2S,4S)-2-[N-(benzyloxycarbonyl)-N-methylamino]-5,5-dichloro-4-methylpentanoic acid methyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2S,4S)-2-[N-(benzyloxycarbonyl)-N-methylamino]-5,5-dichloro-4-methylpentanoic acid methyl ester

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Technology Process of (2S,4S)-2-[N-(benzyloxycarbonyl)-N-methylamino]-5,5-dichloro-4-methylpentanoic acid methyl ester

There total 1 articles about (2S,4S)-2-[N-(benzyloxycarbonyl)-N-methylamino]-5,5-dichloro-4-methylpentanoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 916675-81-5
(2S,4S)-2-[(benzyloxycarbonyl)amino]-5,5-dichloro-4-methylpentanoic acid

: 74-88-4
methyl iodide

: 916675-82-6
(2S,4S)-2-[N-(benzyloxycarbonyl)-N-methylamino]-5,5-dichloro-4-methylpentanoic acid methyl ester

Guidance literature:: With sodium hydride; In tetrahydrofuran; N,N-dimethyl-formamide; for 24h; Heating;
DOI:10.1021/ol062279f

Reference yield:

: 916675-82-6
(2S,4S)-2-[N-(benzyloxycarbonyl)-N-methylamino]-5,5-dichloro-4-methylpentanoic acid methyl ester

: 916675-85-9
(2S,4S)-2-{[(2S,4S)-2-(Benzyloxycarbonyl-methyl-amino)-5,5-dichloro-4-methyl-pentanoyl]-methyl-amino}-5,5-dichloro-4-methyl-pentanoic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 91 percent / hydrobromic acid; acetic acid / 2 h

2: 54 percent / Et₃N; BOPCl / CH₂Cl₂ / 0 °C

With hydrogen bromide; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; acetic acid; triethylamine; In dichloromethane;
DOI:10.1021/ol062279f