6-Fluoro-2-(oxiran-2-yl)chroman

Base Information

Chemical Name:6-Fluoro-2-(oxiran-2-yl)chroman
CAS No.:197706-51-7
Molecular Formula:C₁₁H₁₁FO₂
Molecular Weight:194.206
Hs Code.:
European Community (EC) Number:419-600-2,419-630-6,603-314-1,606-373-1,606-374-7,616-687-0,618-039-2,619-407-5
DSSTox Substance ID:DTXSID40470147

Synonyms:6-fluoro-2-(oxiran-2-yl)chroman;99199-90-3;6-Fluoro-3,4-dihydro-2-oxiranyl-2H-1-benzopyran;6-fluoro-2-(oxiran-2-yl)-3,4-dihydro-2H-chromene;6-fluoro-2-(oxiran-2-yl)chromane;(2R)-rel-6-Fluoro-3,4-dihydro-2-[(2S)-2-oxiranyl]-2H-1-benzopyran;6-FLUORO-2-(OXIRAN-2-YL)-3,4-DIHYDRO-2H-1-BENZOPYRAN;197706-51-7;793669-26-8;(2S, 2'S)-6-Fluoro-2-(2'-oxiranyl)chromane;129050-23-3;197706-50-6;6-Fluoro-3,4-dihydro-2-(2-oxiranyl)-2H-1-benzopyran;(2R,2'R)-6-Fluoro-2-(2'-oxiranyl)chromane;SCHEMBL965195;(2S)-6-fluoro-2-[(2S)-oxiran-2-yl]-3,4-dihydro-2H-chromene;DTXSID40470147;GVZDIJGBXSDSEP-UHFFFAOYSA-N;876514-31-7;AMY33403;BCP14120;MFCD32196859;ZB1812;AKOS006307171;(2R)-6-Fluoro-2-(oxiran-2-yl)chroman;SY344686;FT-0654423;FT-0668675;FT-0668676;FT-0778639;FT-0778640;NS00002314;N-Nitro-1,2,3,4-tetradehydro Argatroban-d8;D87510;EC 606-373-1;Fluoro-3,4-dihydro-2-oxiranyl-2H-1-benzopyran;A845980;6-fluoro-3, 4-dihydro-2-oxiranyl-2h-1-benzopyran;Q-200005;6-fluoranyl-2-(oxiran-2-yl)-3,4-dihydro-2H-chromene;6-fluoro-2-(2-oxiranyl)-3,4-dihydro-2H-1-benzopyran;(-)-(R,R)-6-Fluoro-3,4-dihydro-2-(2-oxiranyl)-2H-1-benzopyran;(+/-)-(R*,R* and R*,S*)-6-Fluoro-3,4-dihydro-2-oxiranyl-2H-1-benzopyran

Suppliers and Price of 6-Fluoro-2-(oxiran-2-yl)chroman

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
(2S,2’R)-6-Fluoro-2-(2’-oxiranyl)chromane
100mg
$ 1540.00

Total 8 raw suppliers

Chemical Property of 6-Fluoro-2-(oxiran-2-yl)chroman

Chemical Property:

Vapor Pressure:0.00334mmHg at 25°C
Boiling Point:285.4℃ at 102kPa
Density:1.38g/cm3 at 20℃
XLogP3:2.1
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:194.07430775
Heavy Atom Count:14
Complexity:221

Purity/Quality:

99.9% ^*data from raw suppliers

(2S,2’R)-6-Fluoro-2-(2’-oxiranyl)chromane ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1CC2=C(C=CC(=C2)F)OC1C3CO3
Uses (2S,2’R)-6-Fluoro-2-(2’-oxiranyl)chromane is an intermediate to synthesize Nebivolol (rac, HCl salt, N387900) which is a β1-Adrenergic blocker.

Technology Process of 6-Fluoro-2-(oxiran-2-yl)chroman

There total 12 articles about 6-Fluoro-2-(oxiran-2-yl)chroman which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.5%

: 1315508-96-3
(S)-2-chloro-1-((S)-6-fluoro-3,4-dihydro-2H-chromen-2-yl)ethanol

: 197706-51-7,793669-26-8,876514-31-7
(S)-6-fluoro-2-((R)-oxiran-2-yl)chroman

Guidance literature:: With sodium hydroxide; In ethanol; for 4h; Solvent; Reflux;

Reference yield:

: 793669-26-8,876514-31-7
[1S*(R*)]-6-fluoro-3,4-dihydro-2-(oxiran-2-yl)-2H-chromene

: 621-84-1
O-benzyl carbamate

: 197706-51-7,793669-26-8,876514-31-7
(S)-6-fluoro-2-((R)-oxiran-2-yl)chroman

: 1029684-23-8
[(S)-2-((R)-6-fluoro-chroman-2-yI)-2-hydroxy-ethyl]-carbamic acid benzyl ester

Guidance literature:: With oxygen; 4-nitro-benzoic acid; [(S,S)-N,N’-bis(3,5-di-tertbutylsalicylidene)-1,2-cyclohexanediaminato(2-)]cobalt(II); In dichlorormethane; tert-butyl methyl ether; at 20 ℃; for 1h; Product distribution / selectivity;