9-[(4-Carboxy-2,6-diMethylphenoxy)carbonyl]-10-(3-sulfopropyl)acridiniuM Inner Salt

Base Information

• Chemical Name: 9-[(4-Carboxy-2,6-diMethylphenoxy)carbonyl]-10-(3-sulfopropyl)acridiniuM Inner Salt
• CAS No.: 946423-58-1
• Molecular Formula: C₂₆H₂₃NO₇S
• Molecular Weight: 493.537
• Mol file: 946423-58-1.mol

Synonyms:2',6'-dimethyl-4'-carboxyphenyl-10-sulfopropylacridinium-9-carboxylate

Chemical Property of 9-[(4-Carboxy-2,6-diMethylphenoxy)carbonyl]-10-(3-sulfopropyl)acridiniuM Inner Salt

Chemical Property:

• Melting Point: >207°C (dec.)
• Storage Temp.: Amber Vial, -20°C Freezer, Under inert atmosphere
• Solubility.: DMSO (Slightly)

Purity/Quality:

9-[(4-Carboxy-2,6-dimethylphenoxy)carbonyl]-10-(3-sulfopropyl)acridiniumInnerSalt(>90%) ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: 9-[(4-Carboxy-2,6-dimethylphenoxy)carbonyl]-10-(3-sulfopropyl)acridinium Inner Salt is an intermediate in synthesis of hydrophilic chemiluminescent acridinium esters containing N-sulfopropyl groups are extremely useful labels in the clinical diagnostics industry especialy in automated immunochemical analyzers such as Siemens Healthcare Diagnostics' ADVIA Centaur systems. 9-[(4-Carboxy-2,6-dimethylphenoxy)carbonyl]-10-(3-sulfopropyl)acridinium Inner Salt is an intermediate in synthesis of hydrophilic chemiluminescent acridinium esters containing N-sulfopropyl groups are extremely useful labels in the clinical diagnostics industry especialy in automated immunochemical analyzers such as Siemens Healthcare Diagnostics'' ADVIA Centaur systems.

Technology Process of 9-[(4-Carboxy-2,6-diMethylphenoxy)carbonyl]-10-(3-sulfopropyl)acridiniuM Inner Salt

There total 1 articles about 9-[(4-Carboxy-2,6-diMethylphenoxy)carbonyl]-10-(3-sulfopropyl)acridiniuM Inner Salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

2'-6'-dimethyl-4'-methoxycarbonylphenyl 10-sulfopropylacridinium-9-carboxylate (946423-59-2) → 2',6'-dimethyl-4'-carboxyphenyl-10-sulfopropylacridinium-9-carboxylate (946423-58-1)

Guidance literature:

With hydrogenchloride; water; at 110 ℃; for 4h; Product distribution / selectivity;

Reference yield:

2',6'-dimethyl-4'-carboxyphenyl-10-sulfopropylacridinium-9-carboxylate (946423-58-1) + O-(N-succinimidyl)-N,N,N',N'-tetramethyluronium tetrafluoroborate (105832-38-0) → NSP-DMAE-NHS ester (194357-64-7)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 0.25h;

Reference yield:

2',6'-dimethyl-4'-carboxyphenyl-10-sulfopropylacridinium-9-carboxylate (946423-58-1) → C36H46N4O9S2 (1307864-26-1)

Guidance literature:

Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.25 h / 20 °C

2: sodium hydrogencarbonate / N,N-dimethyl-formamide / 3 h / 20 °C

With sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide;

upstream raw materials:

2'-6'-dimethyl-4'-methoxycarbonylphenyl 10-sulfopropylacridinium-9-carboxylate

Downstream raw materials:

NSP-DMAE-NHS ester

C₃₆H₄₄N₄O₈S

NSP-DMAE-ZCB-NHS

C₃₆H₄₆N₄O₉S₂