{2-[(S)-1-(tert-Butyl-diphenyl-silanyloxy)-2-oxo-azepan-3-ylcarbamoyl]-ethyl}-carbamic acid benzyl ester

Base Information

Chemical Name:{2-[(S)-1-(tert-Butyl-diphenyl-silanyloxy)-2-oxo-azepan-3-ylcarbamoyl]-ethyl}-carbamic acid benzyl ester
CAS No.:210547-96-9
Molecular Formula:C₃₃H₄₁N₃O₅Si
Molecular Weight:587.791
Hs Code.:

Synonyms:{2-[(S)-1-(tert-Butyl-diphenyl-silanyloxy)-2-oxo-azepan-3-ylcarbamoyl]-ethyl}-carbamic acid benzyl ester

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Chemical Property of {2-[(S)-1-(tert-Butyl-diphenyl-silanyloxy)-2-oxo-azepan-3-ylcarbamoyl]-ethyl}-carbamic acid benzyl ester

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Technology Process of {2-[(S)-1-(tert-Butyl-diphenyl-silanyloxy)-2-oxo-azepan-3-ylcarbamoyl]-ethyl}-carbamic acid benzyl ester

There total 1 articles about {2-[(S)-1-(tert-Butyl-diphenyl-silanyloxy)-2-oxo-azepan-3-ylcarbamoyl]-ethyl}-carbamic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 2304-94-1
3-(benzyloxycarbonylamino)propanoic acid

: 210547-90-3
(S)-3-Amino-1-(tert-butyl-diphenyl-silanyloxy)-azepan-2-one

: 210547-96-9
{2-[(S)-1-(tert-Butyl-diphenyl-silanyloxy)-2-oxo-azepan-3-ylcarbamoyl]-ethyl}-carbamic acid benzyl ester

Guidance literature:: With 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; for 2h; Ambient temperature;
DOI:10.1021/jo980063o

Reference yield:

: 210547-96-9
{2-[(S)-1-(tert-Butyl-diphenyl-silanyloxy)-2-oxo-azepan-3-ylcarbamoyl]-ethyl}-carbamic acid benzyl ester

: 3-Amino-N-[(S)-1-(tert-butyl-diphenyl-silanyloxy)-2-oxo-azepan-3-yl]-propionamide

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol; for 3h; under 735.5 Torr; Ambient temperature;
DOI:10.1021/jo980063o

Reference yield:

: 210547-96-9
{2-[(S)-1-(tert-Butyl-diphenyl-silanyloxy)-2-oxo-azepan-3-ylcarbamoyl]-ethyl}-carbamic acid benzyl ester

: (S)-2-(2-Hydroxy-phenyl)-4,5-dihydro-oxazole-4-carboxylic acid {(S)-5-(hexadecanoyl-hydroxy-amino)-1-[2-((S)-1-hydroxy-2-oxo-azepan-3-ylcarbamoyl)-ethylcarbamoyl]-pentyl}-amide

Guidance literature:: Multi-step reaction with 3 steps

1: H₂ / 10percent Pd-C / methanol / 3 h / 735.5 Torr / Ambient temperature

2: HOAt, EDC-HCl / dimethylformamide / 3.5 h / Ambient temperature

3: 48.6 mg / TBAF, HOAc / tetrahydrofuran / 1 h / 0 - 20 °C

With 1-hydroxy-7-aza-benzotriazole; tetrabutyl ammonium fluoride; hydrogen; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium on activated charcoal; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.1021/jo980063o