(S)-2-(2-Hydroxy-phenyl)-4,5-dihydro-oxazole-4-carboxylic acid [(S)-1-{2-[(S)-1-(tert-butyl-diphenyl-silanyloxy)-2-oxo-azepan-3-ylcarbamoyl]-ethylcarbamoyl}-5-(hexadecanoyl-hydroxy-amino)-pentyl]-amide

Base Information

Chemical Name:(S)-2-(2-Hydroxy-phenyl)-4,5-dihydro-oxazole-4-carboxylic acid [(S)-1-{2-[(S)-1-(tert-butyl-diphenyl-silanyloxy)-2-oxo-azepan-3-ylcarbamoyl]-ethylcarbamoyl}-5-(hexadecanoyl-hydroxy-amino)-pentyl]-amide
CAS No.:370103-06-3
Molecular Formula:C₅₇H₈₄N₆O₉Si
Molecular Weight:1025.41
Hs Code.:

(S)-2-(2-Hydroxy-phenyl)-4,5-dihydro-oxazole-4-carboxylic acid [(S)-1-{2-[(S)-1-(tert-butyl-diphenyl-silanyloxy)-2-oxo-azepan-3-ylcarbamoyl]-ethylcarbamoyl}-5-(hexadecanoyl-hydroxy-amino)-pentyl]-amide

Synonyms:(S)-2-(2-Hydroxy-phenyl)-4,5-dihydro-oxazole-4-carboxylic acid [(S)-1-{2-[(S)-1-(tert-butyl-diphenyl-silanyloxy)-2-oxo-azepan-3-ylcarbamoyl]-ethylcarbamoyl}-5-(hexadecanoyl-hydroxy-amino)-pentyl]-amide

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Chemical Property of (S)-2-(2-Hydroxy-phenyl)-4,5-dihydro-oxazole-4-carboxylic acid [(S)-1-{2-[(S)-1-(tert-butyl-diphenyl-silanyloxy)-2-oxo-azepan-3-ylcarbamoyl]-ethylcarbamoyl}-5-(hexadecanoyl-hydroxy-amino)-pentyl]-amide

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Technology Process of (S)-2-(2-Hydroxy-phenyl)-4,5-dihydro-oxazole-4-carboxylic acid [(S)-1-{2-[(S)-1-(tert-butyl-diphenyl-silanyloxy)-2-oxo-azepan-3-ylcarbamoyl]-ethylcarbamoyl}-5-(hexadecanoyl-hydroxy-amino)-pentyl]-amide

There total 9 articles about (S)-2-(2-Hydroxy-phenyl)-4,5-dihydro-oxazole-4-carboxylic acid [(S)-1-{2-[(S)-1-(tert-butyl-diphenyl-silanyloxy)-2-oxo-azepan-3-ylcarbamoyl]-ethylcarbamoyl}-5-(hexadecanoyl-hydroxy-amino)-pentyl]-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 210547-90-3
(S)-3-Amino-1-(tert-butyl-diphenyl-silanyloxy)-azepan-2-one

: 370103-06-3
(S)-2-(2-Hydroxy-phenyl)-4,5-dihydro-oxazole-4-carboxylic acid [(S)-1-{2-[(S)-1-(tert-butyl-diphenyl-silanyloxy)-2-oxo-azepan-3-ylcarbamoyl]-ethylcarbamoyl}-5-(hexadecanoyl-hydroxy-amino)-pentyl]-amide

Guidance literature:: Multi-step reaction with 3 steps

1: 91 percent / EDC-HCl, HOAt / dimethylformamide / 2 h / Ambient temperature

2: H₂ / 10percent Pd-C / methanol / 3 h / 735.5 Torr / Ambient temperature

3: HOAt, EDC-HCl / dimethylformamide / 3.5 h / Ambient temperature

With 1-hydroxy-7-aza-benzotriazole; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide;
DOI:10.1021/jo980063o

Reference yield:

: 157505-72-1
(S)-2-Benzyloxycarbonylamino-6-hydroxyamino-hexanoic acid methyl ester

: 370103-06-3
(S)-2-(2-Hydroxy-phenyl)-4,5-dihydro-oxazole-4-carboxylic acid [(S)-1-{2-[(S)-1-(tert-butyl-diphenyl-silanyloxy)-2-oxo-azepan-3-ylcarbamoyl]-ethylcarbamoyl}-5-(hexadecanoyl-hydroxy-amino)-pentyl]-amide

Guidance literature:: Multi-step reaction with 5 steps

1: NaHCO₃ / CH₂Cl₂ / 14 h / Ambient temperature

2: H₂ / 10percent Pd-C / methanol / 3 h / 735.5 Torr / Ambient temperature

3: 91 percent / HOAt, EDC-HCl / dimethylformamide / 3 h / Ambient temperature

4: LiOH

5: HOAt, EDC-HCl / dimethylformamide / 3.5 h / Ambient temperature

With lithium hydroxide; 1-hydroxy-7-aza-benzotriazole; hydrogen; sodium hydrogencarbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium on activated charcoal; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo980063o

Reference yield:

: 171287-53-9
(S)-2-Benzyloxycarbonylamino-6-(hexadecanoyl-hydroxy-amino)-hexanoic acid methyl ester

: 370103-06-3
(S)-2-(2-Hydroxy-phenyl)-4,5-dihydro-oxazole-4-carboxylic acid [(S)-1-{2-[(S)-1-(tert-butyl-diphenyl-silanyloxy)-2-oxo-azepan-3-ylcarbamoyl]-ethylcarbamoyl}-5-(hexadecanoyl-hydroxy-amino)-pentyl]-amide

Guidance literature:: Multi-step reaction with 4 steps

1: H₂ / 10percent Pd-C / methanol / 3 h / 735.5 Torr / Ambient temperature

2: 91 percent / HOAt, EDC-HCl / dimethylformamide / 3 h / Ambient temperature

3: LiOH

4: HOAt, EDC-HCl / dimethylformamide / 3.5 h / Ambient temperature

With lithium hydroxide; 1-hydroxy-7-aza-benzotriazole; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide;
DOI:10.1021/jo980063o