(E)-2-ethyl-2-hydroxy-N,N-diethyl-4-(phenylthio)but-3-enamide

Base Information

• Chemical Name: (E)-2-ethyl-2-hydroxy-N,N-diethyl-4-(phenylthio)but-3-enamide
• CAS No.: 1291076-21-5
• Molecular Formula: C₁₆H₂₃NO₂S
• Molecular Weight: 293.43
• Mol file: 1291076-21-5.mol

Synonyms:(E)-2-ethyl-2-hydroxy-N,N-diethyl-4-(phenylthio)but-3-enamide

Chemical Property of (E)-2-ethyl-2-hydroxy-N,N-diethyl-4-(phenylthio)but-3-enamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-2-ethyl-2-hydroxy-N,N-diethyl-4-(phenylthio)but-3-enamide

There total 2 articles about (E)-2-ethyl-2-hydroxy-N,N-diethyl-4-(phenylthio)but-3-enamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C19H31NO2SSi → (E)-2-ethyl-2-hydroxy-N,N-diethyl-4-(phenylthio)but-3-enamide (1291076-21-5)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; for 1.5h; Inert atmosphere;

DOI:10.1016/j.tet.2011.02.017

Reference yield:

N,N-diethyl-2-oxo-4-(phenylthio)-4-(trimethylsilyl)but-3-enamide (1291076-19-1) → (E)-2-ethyl-2-hydroxy-N,N-diethyl-4-(phenylthio)but-3-enamide (1291076-21-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: tetrahydrofuran / 2.5 h / -65 - -30 °C / Inert atmosphere

1.2: Inert atmosphere

2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1.5 h / Inert atmosphere

With tetrabutyl ammonium fluoride; In tetrahydrofuran;

DOI:10.1016/j.tet.2011.02.017

Reference yield: 73.0%

(E)-2-ethyl-2-hydroxy-N,N-diethyl-4-(phenylthio)but-3-enamide (1291076-21-5) → (E)-2-ethyl-2-hydroxy-N,N-diethyl-4-(phenylsulfonyl)but-3-enamide (1291076-23-7)

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 0 ℃; for 2h; Inert atmosphere;

DOI:10.1016/j.tet.2011.02.017

upstream raw materials:

N,N-diethyl-2-oxo-4-(phenylthio)-4-(trimethylsilyl)but-3-enamide

Downstream raw materials:

(E)-2-ethyl-2-hydroxy-N,N-diethyl-4-(phenylsulfonyl)but-3-enamide

(E)-3-(diethylcarbamoyl)-1-(phenylsulfonyl)pent-1-en-3-yl 3-oxo-3-(2-oxopyrrolidin-1-yl)propanoate

(E)-3-(diethylcarbamoyl)-1-(phenylsulfonyl)pent-1-en-3-yl 2-diazo-3-oxo-3-(2-oxopyrrolidin-1-yl)propanoate

1-ethyl-N,N-diethyl-3,4-dioxo-9-(phenylsulfonyl)-1,3,4,6,7,8-hexahydrofuro[3,4-f]indolizine-1-carboxamide