[(4,7-bis{[hydroxy(methyl)phosphoryl]methyl}-10-({[2-(trifluoromethyl)phenyl]carbamoyl}methyl)-1,4,7,10-tetraazacyclododecan-1-yl)methyl](methyl)phosphinic acid

Base Information

Chemical Name:[(4,7-bis{[hydroxy(methyl)phosphoryl]methyl}-10-({[2-(trifluoromethyl)phenyl]carbamoyl}methyl)-1,4,7,10-tetraazacyclododecan-1-yl)methyl](methyl)phosphinic acid
CAS No.:1269772-27-1
Molecular Formula:C₂₃H₄₁F₃N₅O₇P₃
Molecular Weight:649.524
Hs Code.:

[(4,7-bis{[hydroxy(methyl)phosphoryl]methyl}-10-({[2-(trifluoromethyl)phenyl]carbamoyl}methyl)-1,4,7,10-tetraazacyclododecan-1-yl)methyl](methyl)phosphinic acid

Synonyms:[(4,7-bis{[hydroxy(methyl)phosphoryl]methyl}-10-({[2-(trifluoromethyl)phenyl]carbamoyl}methyl)-1,4,7,10-tetraazacyclododecan-1-yl)methyl](methyl)phosphinic acid

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Chemical Property of [(4,7-bis{[hydroxy(methyl)phosphoryl]methyl}-10-({[2-(trifluoromethyl)phenyl]carbamoyl}methyl)-1,4,7,10-tetraazacyclododecan-1-yl)methyl](methyl)phosphinic acid

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Technology Process of [(4,7-bis{[hydroxy(methyl)phosphoryl]methyl}-10-({[2-(trifluoromethyl)phenyl]carbamoyl}methyl)-1,4,7,10-tetraazacyclododecan-1-yl)methyl](methyl)phosphinic acid

There total 4 articles about [(4,7-bis{[hydroxy(methyl)phosphoryl]methyl}-10-({[2-(trifluoromethyl)phenyl]carbamoyl}methyl)-1,4,7,10-tetraazacyclododecan-1-yl)methyl](methyl)phosphinic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 1269772-32-8
ethyl [(4,7-bis{[ethoxy(methyl)phosphoryl]methyl}-10-({[2-(trifluoromethyl)phenyl]carbamoyl}methyl)-1,4,7,10-tetraazacyclododecan-1-yl)methyl](methyl)phosphinate

: 1269772-27-1
[(4,7-bis{[hydroxy(methyl)phosphoryl]methyl}-10-({[2-(trifluoromethyl)phenyl]carbamoyl}methyl)-1,4,7,10-tetraazacyclododecan-1-yl)methyl](methyl)phosphinic acid

Guidance literature:: With potassium deuterohydroxide; In water; at 40 ℃; for 4h; Inert atmosphere;
DOI:10.1039/c0dt01232g

Reference yield:

: 1269772-31-7
2-(1,4,7,10-tetraazacyclododec-1-yl)-N-(2-trifluorometylphenyl)acetamide

: 1269772-27-1
[(4,7-bis{[hydroxy(methyl)phosphoryl]methyl}-10-({[2-(trifluoromethyl)phenyl]carbamoyl}methyl)-1,4,7,10-tetraazacyclododecan-1-yl)methyl](methyl)phosphinic acid

Guidance literature:: Multi-step reaction with 2 steps

1: tetrahydrofuran / 15 h / 80 °C / Inert atmosphere; Reflux; Molecular sieve

2: potassium deuterohydroxide / water / 4 h / 40 °C / Inert atmosphere

With potassium deuterohydroxide; In tetrahydrofuran; water;
DOI:10.1039/c0dt01232g

Reference yield:

: 3792-04-9
2-chloro-N-[2-(trifluoromethyl)phenyl]acetamide

: 1269772-27-1
[(4,7-bis{[hydroxy(methyl)phosphoryl]methyl}-10-({[2-(trifluoromethyl)phenyl]carbamoyl}methyl)-1,4,7,10-tetraazacyclododecan-1-yl)methyl](methyl)phosphinic acid

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / acetonitrile / 16 h / 55 °C / Inert atmosphere

2: tetrahydrofuran / 15 h / 80 °C / Inert atmosphere; Reflux; Molecular sieve

3: potassium deuterohydroxide / water / 4 h / 40 °C / Inert atmosphere

With potassium deuterohydroxide; potassium carbonate; In tetrahydrofuran; water; acetonitrile;
DOI:10.1039/c0dt01232g