ETHYL 2-METHYLPHENYLALANINE

Base Information

• Chemical Name: ETHYL 2-METHYLPHENYLALANINE
• CAS No.: 46438-07-7
• Molecular Formula: C12H17 N O2
• Molecular Weight: 207.272
• Mol file: 46438-07-7.mol

Synonyms:DL-Phenylalanine,a-methyl-, ethyl ester; (?à)-2-Amino-2-methyl-3-phenylpropionicacid ethyl ester; 2-Amino-2-methyl-3-phenylpropionic acid ethyl ester

Chemical Property of ETHYL 2-METHYLPHENYLALANINE

Chemical Property:

Purity/Quality:

98%min ^*data from raw suppliers

ethyl2-amino-2-methyl-3-phenylpropanoate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ETHYL 2-METHYLPHENYLALANINE

There total 20 articles about ETHYL 2-METHYLPHENYLALANINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

benzyl bromide (100-39-0) + ethyl (RS)-2-(benzylideneamino)propanoate (60930-36-1) → α-methyl-α-carbethoxy-β-phenethylamine (46438-07-7)

Guidance literature:

With cesiumhydroxide monohydrate; 2Br^(1-)*C₅₉H₆₄N₄O₃⁽²⁺⁾; In chloroform; toluene; at -10 ℃; for 4h;

DOI:10.1039/c7ra12499f

Reference yield: 90.0%

ethyl 2-methyl-2-nitro-3-phenyl-propionate (114858-61-6) → α-methyl-α-carbethoxy-β-phenethylamine (46438-07-7)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; at 20 ℃; for 12h;

DOI:10.1021/jo0709450

Reference yield: 84.0%

ethyl 2-azido-2-methyl-3-phenylpropanoate (849371-87-5) → α-methyl-α-carbethoxy-β-phenethylamine (46438-07-7)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In tetrahydrofuran; at 20 ℃; for 0.5h;

DOI:10.1016/j.tetlet.2015.01.041

upstream raw materials:

ethanol

2-methyl-3-phenylalanine

(+/-)-2-(2-Carboethoxy-1-phenyl)propylisocyanid

ethyl 2-benzyl-2-(4-methoxyphenyl)aminopropionate

Downstream raw materials:

4-acetyl-3-benzyl-1,3-dimethylpiperazine-2,5-dione

1,4-diacetyl-3-benzyl-3-methylpiperazine-2,5-dione

3-benzyl-1,3-dimethylpiperazine-2,5-dione

3-benzyl-3-methyl-piperazine-2,5-dione