5-Pyrimidinecarboxylicacid,4-hexyl-1,2,3,4-tetrahydro-6-methyl-2-oxo-,methylester(9CI)

Base Information

Chemical Name:5-Pyrimidinecarboxylicacid,4-hexyl-1,2,3,4-tetrahydro-6-methyl-2-oxo-,methylester(9CI)
CAS No.:349650-89-1
Molecular Formula:C₁₃H₂₂N₂O₃
Molecular Weight:254.329
Hs Code.:
Mol file:349650-89-1.mol

Synonyms:5-Pyrimidinecarboxylicacid,4-hexyl-1,2,3,4-tetrahydro-6-methyl-2-oxo-,methylester(9CI)

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5-Pyrimidinecarboxylicacid,4-hexyl-1,2,3,4-tetrahydro-6-methyl-2-oxo-,methylester(9CI)

Chemical Property:

PSA：70.92000
LogP:2.05400

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 5-Pyrimidinecarboxylicacid,4-hexyl-1,2,3,4-tetrahydro-6-methyl-2-oxo-,methylester(9CI)

There total 2 articles about 5-Pyrimidinecarboxylicacid,4-hexyl-1,2,3,4-tetrahydro-6-methyl-2-oxo-,methylester(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 111-71-7
heptanal

: 105-45-3
acetoacetic acid methyl ester

: 57-13-6
urea

: 349650-89-1
methyl (R)-4-hexyl-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

: 349650-89-1
methyl (S)-4-hexyl-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

Guidance literature:: heptanal; urea; With (R)-3,3'-bis(3,5-di-tert-butyl-4-methoxyphenyl)-1,1'-binaphthyl-2,2'-dihydrogenphosphoric acid; In chloroform; at 25 ℃; for 2h;

acetoacetic acid methyl ester; In chloroform; at 25 - 50 ℃; for 264h; Overall yield = 76 %; enantioselective reaction;
DOI:10.1055/s-0036-1591567

Reference yield: 65.0%

: 111-71-7
heptanal

: 105-45-3
acetoacetic acid methyl ester

: 57-13-6
urea

: 349650-89-1
methyl (R)-4-hexyl-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

: 349650-89-1
methyl (S)-4-hexyl-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

Guidance literature:: heptanal; urea; With (R)-3,3'-bis(3,5-di-tert-butyl-4-methoxyphenyl)-1,1'-binaphthyl-2,2'-dihydrogenphosphoric acid; In chloroform; at 25 ℃; for 2h;

acetoacetic acid methyl ester; In chloroform; at 25 - 50 ℃; for 264h; Overall yield = 76 %; enantioselective reaction;
DOI:10.1055/s-0036-1591567