methyl (S) [N-(tert-butoxycarbonyl)-O-tert-butyldimethylsilyl]tyrosylglycylglycinate

Base Information

• Chemical Name: methyl (S) [N-(tert-butoxycarbonyl)-O-tert-butyldimethylsilyl]tyrosylglycylglycinate
• CAS No.: 1332726-69-8
• Molecular Formula: C₂₅H₄₁N₃O₇Si
• Molecular Weight: 523.702
• Mol file: 1332726-69-8.mol

Synonyms:methyl (S) [N-(tert-butoxycarbonyl)-O-tert-butyldimethylsilyl]tyrosylglycylglycinate

Chemical Property of methyl (S) [N-(tert-butoxycarbonyl)-O-tert-butyldimethylsilyl]tyrosylglycylglycinate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl (S) [N-(tert-butoxycarbonyl)-O-tert-butyldimethylsilyl]tyrosylglycylglycinate

There total 1 articles about methyl (S) [N-(tert-butoxycarbonyl)-O-tert-butyldimethylsilyl]tyrosylglycylglycinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

(S)-2-(2-N-tert-butoxycarbonylamino)-3-[4-(tert-butyldimethylsilyloxy)phenyl]-propanoic acid (94732-15-7) + glycylglycine methyl ester trifluoroacetic acid salt (96212-26-9) → methyl (S) [N-(tert-butoxycarbonyl)-O-tert-butyldimethylsilyl]tyrosylglycylglycinate (1332726-69-8)

Guidance literature:

With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 97h; Inert atmosphere;

DOI:10.1080/10426507.2010.535398

Reference yield: 51.0%

methyl (S) [N-(tert-butoxycarbonyl)-O-tert-butyldimethylsilyl]tyrosylglycylglycinate (1332726-69-8) → TBDMS-O-Boc-N-Tyr-Gly-Gly-OH (1332726-72-3) + tyrosylglycylglycine (21778-69-8) + tert-butoxycarbonyl-L-tyrosyl-glycyl-glycine (59481-76-4)

Guidance literature:

With water; lithium hydroxide; In methanol; at 20 ℃; for 17h; Inert atmosphere;

DOI:10.1080/10426507.2010.535398

Reference yield:

methyl (S) [N-(tert-butoxycarbonyl)-O-tert-butyldimethylsilyl]tyrosylglycylglycinate (1332726-69-8) → tert-butoxycarbonyl-L-tyrosyl-glycyl-glycine (59481-76-4)

Guidance literature:

Multi-step reaction with 2 steps

1: water; lithium hydroxide / methanol / 17 h / 20 °C / Inert atmosphere

2: potassium carbonate

With water; potassium carbonate; lithium hydroxide; In methanol;

DOI:10.1080/10426507.2010.535398

upstream raw materials:

(S)-2-(2-N-tert-butoxycarbonylamino)-3-[4-(tert-butyldimethylsilyloxy)phenyl]-propanoic acid

glycylglycine methyl ester trifluoroacetic acid salt

Downstream raw materials:

TBDMS-O-Boc-N-Tyr-Gly-Gly-OH

tyrosylglycylglycine

tert-butoxycarbonyl-L-tyrosyl-glycyl-glycine