2-(2-(benzyloxy)pyridin-3-ylamino)-9-((1R,4R)-4-(tert-butyldiphenylsilyloxy)-1,2,3,4-tetrahydronaphthalen-1-yl)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-purin-8(9H)-one

Base Information

Chemical Name:2-(2-(benzyloxy)pyridin-3-ylamino)-9-((1R,4R)-4-(tert-butyldiphenylsilyloxy)-1,2,3,4-tetrahydronaphthalen-1-yl)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-purin-8(9H)-one
CAS No.:1415151-96-0
Molecular Formula:C₄₉H₅₆N₆O₄Si₂
Molecular Weight:849.192
Hs Code.:

2-(2-(benzyloxy)pyridin-3-ylamino)-9-((1R,4R)-4-(tert-butyldiphenylsilyloxy)-1,2,3,4-tetrahydronaphthalen-1-yl)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-purin-8(9H)-one

Synonyms:2-(2-(benzyloxy)pyridin-3-ylamino)-9-((1R,4R)-4-(tert-butyldiphenylsilyloxy)-1,2,3,4-tetrahydronaphthalen-1-yl)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-purin-8(9H)-one

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Chemical Property of 2-(2-(benzyloxy)pyridin-3-ylamino)-9-((1R,4R)-4-(tert-butyldiphenylsilyloxy)-1,2,3,4-tetrahydronaphthalen-1-yl)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-purin-8(9H)-one

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Technology Process of 2-(2-(benzyloxy)pyridin-3-ylamino)-9-((1R,4R)-4-(tert-butyldiphenylsilyloxy)-1,2,3,4-tetrahydronaphthalen-1-yl)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-purin-8(9H)-one

There total 9 articles about 2-(2-(benzyloxy)pyridin-3-ylamino)-9-((1R,4R)-4-(tert-butyldiphenylsilyloxy)-1,2,3,4-tetrahydronaphthalen-1-yl)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-purin-8(9H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 1415151-92-6
9-((1R,4R)-4-(tert-butyldiphenylsilyloxy)-1,2,3,4-tetrahydronaphthalen-1-yl)-2-chloro-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-purin-8(9H)-one

: 23845-96-7
2-(benzyloxy)pyridin-3-amine

: 1415151-96-0
2-(2-(benzyloxy)pyridin-3-ylamino)-9-((1R,4R)-4-(tert-butyldiphenylsilyloxy)-1,2,3,4-tetrahydronaphthalen-1-yl)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-purin-8(9H)-one

Guidance literature:: With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; at 100 ℃; for 24h; Schlenk technique; Inert atmosphere;
DOI:10.1021/acs.jmedchem.9b00533

Reference yield: 79.0%

: 1415151-96-0
2-(2-(benzyloxy)pyridin-3-ylamino)-9-((1R,4R)-4-(tert-butyldiphenylsilyloxy)-1,2,3,4-tetrahydronaphthalen-1-yl)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-purin-8(9H)-one

Guidance literature:

Reference yield:

: 1415151-93-7
N⁴-((1R,4R)-4-(tert-butyldiphenylsilyloxy)-1,2,3,4-tetrahydronaphthalen-1-yl)-2-chloropyrimidine-4,5-diamine

: 1415151-96-0
2-(2-(benzyloxy)pyridin-3-ylamino)-9-((1R,4R)-4-(tert-butyldiphenylsilyloxy)-1,2,3,4-tetrahydronaphthalen-1-yl)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-purin-8(9H)-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: acetonitrile / 3 h / 80 °C / Sealed tube

2.1: sodium hydride / mineral oil; N,N-dimethyl-formamide / 0.25 h / 0 °C / Inert atmosphere

2.2: 2 h / 20 °C / Inert atmosphere

3.1: caesium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 24 h / 100 °C / Schlenk technique; Inert atmosphere

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sodium hydride; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; N,N-dimethyl-formamide; acetonitrile; mineral oil;
DOI:10.1021/acs.jmedchem.9b00533