GSK 525762A

Base Information

Chemical Name:GSK 525762A
CAS No.:1260907-17-2
Molecular Formula:C22H22ClN5O2
Molecular Weight:423.902
Hs Code.:
Mol file:1260907-17-2.mol

Synonyms:I-BET-762;GSK525762;Cibinetide;Molibresib;GSK 525762A;IBET762(GSK525762A);Molibresib (I-BET762;GSK525762 (I-BET-762);GSK 525762A USP/EP/BP;GSK 525762A (I-BET-762)

Suppliers and Price of GSK 525762A

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
GSK 525762A
100mg
$ 1805.00

Usbiological
GSK 525762A
100mg
$ 1677.00

TRC
GSK525762A
10mg
$ 165.00

Tocris
I-BET762 ≥98%(HPLC)
25
$ 393.00

Matrix Scientific
(S)-2-(6-(4-Chlorophenyl)-8-methoxy-1-methyl-4H-benzo-[f][1,2,4]triazolo[4,3-a][1,4]diazepin-4-yl)-N-ethylacetamide 97%
1g
$ 1980.00

Matrix Scientific
(S)-2-(6-(4-Chlorophenyl)-8-methoxy-1-methyl-4H-benzo-[f][1,2,4]triazolo[4,3-a][1,4]diazepin-4-yl)-N-ethylacetamide 97%
5g
$ 9900.00

DC Chemicals
GSK525762A(MolibresibI-BET762) >98%
100 mg
$ 450.00

DC Chemicals
GSK525762A(MolibresibI-BET762) >98%
1 g
$ 1600.00

DC Chemicals
GSK525762A(MolibresibI-BET762) >98%
250 mg
$ 800.00

Crysdot
GSK525762A 98+%
50mg
$ 780.00

Total 32 raw suppliers

Chemical Property of GSK 525762A

Chemical Property:

PKA:15.71±0.46(Predicted)
PSA：84.89000
Density:1.35
LogP:3.93190
Storage Temp.:2-8°C
Solubility.:Soluble in DMSO (up to at least 25 mg/ml) or in Ethanol (up to at least 25 mg/ml)

Purity/Quality:

99%, ^*data from raw suppliers

GSK 525762A ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Description The bromodomain and extra terminal domain (BET) family of proteins, including BRD2, BRD3, and BRD4, affect inflammatory gene expression by controlling the assembly of histone acetylation-dependent chromatin complexes. I-BET762 is a synthetic compound which interacts with BET proteins with high-affinity (Kd = 32.5-42.5 nM). It blocks binding of BET proteins with acetylated histones, disrupting the formation of chromatin complexes involved in the expression of specific inflammatory genes in activated macrophages. Through these actions, I-BET762 provides protection against bacteria-induced sepsis and lipopolysaccharide-triggered endotoxic shock.
Uses GSK 525762A, is a BET Bromodomain Inhibitor, which is now in clinical development. BET bromodomains have emerged as promising drug targets for treatment of cancers, inflammatory diseases, and other medical conditions.

Technology Process of GSK 525762A

There total 18 articles about GSK 525762A which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 67-56-1
methanol

: 75-04-7,85404-22-4
ethylamine

: 1260907-17-2
2-[(4S)-6-(4-chlorophenyl)-1-methyl-8-(methyloxy)-4H-[1,2,4]triazolo[4,3-a][1,4] benzodiazepin-4-yl]-N-ethylacetamide

Guidance literature:: With DIEA; HBTU; In tetrahydrofuran; 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran; acetonitrile;

Reference yield: 47.0%

: 1300019-38-8
[(4S)-6-(4-chlorophenyl)-1-methyl-8-(methyloxy)-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl]acetic acid

: 75-04-7,85404-22-4
ethylamine

: 1260907-17-2
2-[(4S)-6-(4-chlorophenyl)-1-methyl-8-(methyloxy)-4H-[1,2,4]triazolo[4,3-a][1,4] benzodiazepin-4-yl]-N-ethylacetamide

Guidance literature:: [(4S)-6-(4-chlorophenyl)-1-methyl-8-(methyloxy)-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl]acetic acid; With N-ethyl-N,N-diisopropylamine; HATU; In tetrahydrofuran; at 20 ℃; for 3h;

ethylamine; In tetrahydrofuran; for 48h;

Reference yield:

: 1300019-48-0
methyl N¹-[2-[(4-chlorophenyl)carbonyl]-4-(methyloxy)phenyl]-N²-{[(9H-fluoren-9-ylmethyl)oxy]carbonyl}-L-α-asparaginate

: 1260907-17-2
2-[(4S)-6-(4-chlorophenyl)-1-methyl-8-(methyloxy)-4H-[1,2,4]triazolo[4,3-a][1,4] benzodiazepin-4-yl]-N-ethylacetamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: triethylamine / dichloromethane / 24 h / Reflux

2.1: acetic acid / 1,2-dichloro-ethane / 2 h / 60 °C

3.1: tetraphosphorus decasulfide; sodium carbonate / 1,2-dichloro-ethane / 2 h / 70 °C

4.1: hydrazine hydrate / tetrahydrofuran / 4 h / 0 - 15 °C

5.1: triethylamine / tetrahydrofuran / 1 h / 20 °C

6.1: acetic acid / tetrahydrofuran / 48 h / 20 °C

7.1: sodium hydroxide / tetrahydrofuran / 5 h / 20 °C

8.1: N-ethyl-N,N-diisopropylamine; HATU / tetrahydrofuran / 3 h / 20 °C

8.2: 48 h

With tetraphosphorus decasulfide; sodium carbonate; hydrazine hydrate; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; sodium hydroxide; In tetrahydrofuran; dichloromethane; 1,2-dichloro-ethane;