(2S,3R,E)-3-[2-(benzyloxy)ethyl]-6-(methoxymethoxy)-2-(2-methoxyphenyl)hex-4-enoic acid

Base Information

Chemical Name:(2S,3R,E)-3-[2-(benzyloxy)ethyl]-6-(methoxymethoxy)-2-(2-methoxyphenyl)hex-4-enoic acid
CAS No.:1630067-74-1
Molecular Formula:C₂₄H₃₀O₆
Molecular Weight:414.499
Hs Code.:

Synonyms:(2S,3R,E)-3-[2-(benzyloxy)ethyl]-6-(methoxymethoxy)-2-(2-methoxyphenyl)hex-4-enoic acid

Suppliers and Price of (2S,3R,E)-3-[2-(benzyloxy)ethyl]-6-(methoxymethoxy)-2-(2-methoxyphenyl)hex-4-enoic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (2S,3R,E)-3-[2-(benzyloxy)ethyl]-6-(methoxymethoxy)-2-(2-methoxyphenyl)hex-4-enoic acid

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2S,3R,E)-3-[2-(benzyloxy)ethyl]-6-(methoxymethoxy)-2-(2-methoxyphenyl)hex-4-enoic acid

There total 2 articles about (2S,3R,E)-3-[2-(benzyloxy)ethyl]-6-(methoxymethoxy)-2-(2-methoxyphenyl)hex-4-enoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.3%

: 1630067-73-0
(R,E)-6-(benzyloxy)-1-(methoxymethoxy)hex-3-en-2-yl 2-(2-methoxyphenyl)acetate

: 1630067-74-1
(2S,3R,E)-3-[2-(benzyloxy)ethyl]-6-(methoxymethoxy)-2-(2-methoxyphenyl)hex-4-enoic acid

Guidance literature:: With chloro-trimethyl-silane; lithium hexamethyldisilazane; In tetrahydrofuran; diethyl ether; at -78 - -20 ℃; for 2.75h; Inert atmosphere;
DOI:10.1002/ejoc.201402452

Reference yield:

: 1630067-58-1
(R,E)-6-(benzyloxy)-1-(methoxymethoxy)hex-3-en-2-ol

: 1630067-74-1
(2S,3R,E)-3-[2-(benzyloxy)ethyl]-6-(methoxymethoxy)-2-(2-methoxyphenyl)hex-4-enoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: dicyclohexyl-carbodiimide; dmap / dichloromethane / 3 h / 0 °C / Inert atmosphere

2: chloro-trimethyl-silane; lithium hexamethyldisilazane / tetrahydrofuran; diethyl ether / 2.75 h / -78 - -20 °C / Inert atmosphere

With dmap; chloro-trimethyl-silane; dicyclohexyl-carbodiimide; lithium hexamethyldisilazane; In tetrahydrofuran; diethyl ether; dichloromethane;
DOI:10.1002/ejoc.201402452

Reference yield: 93.4%

: 1630067-74-1
(2S,3R,E)-3-[2-(benzyloxy)ethyl]-6-(methoxymethoxy)-2-(2-methoxyphenyl)hex-4-enoic acid

: 1630067-75-2
(2S,3R,E)-3-[2-(benzyloxy)ethyl]-6-(methoxymethoxy)-2-(2-methoxyphenyl)hex-4-enamide

Guidance literature:: (2S,3R,E)-3-[2-(benzyloxy)ethyl]-6-(methoxymethoxy)-2-(2-methoxyphenyl)hex-4-enoic acid; With pyridine; di-tert-butyl dicarbonate; In ethyl acetate; at 20 ℃; for 3.5h; Inert atmosphere;

With ammonium hydroxide; In ethyl acetate; for 1h; Inert atmosphere;
DOI:10.1002/ejoc.201402452