2'-Iodo-6'-methoxyacetophenone

Base Information

Chemical Name:2'-Iodo-6'-methoxyacetophenone
CAS No.:380225-69-4
Molecular Formula:C₉H₉IO₂
Molecular Weight:276.074
Hs Code.:2914500090
DSSTox Substance ID:DTXSID901297776
Nikkaji Number:J1.596.614I

Synonyms:380225-69-4;2'-Iodo-6'-methoxyacetophenone;1-(2-Iodo-6-methoxyphenyl)ethanone;1-(2-iodo-6-methoxyphenyl)ethan-1-one;Ethanone, 1-(2-iodo-6-methoxyphenyl)-;SCHEMBL19068096;AGQMEJMWEADOBC-UHFFFAOYSA-;DTXSID901297776;InChI=1/C9H9IO2/c1-6(11)9-7(10)4-3-5-8(9)12-2/h3-5H,1-2H3

Suppliers and Price of 2'-Iodo-6'-methoxyacetophenone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Chemcia Scientific
1-(2-Iodo-6-methoxy-phenyl)-ethanone 95%
2.5 G
$ 995.00

Total 2 raw suppliers

Chemical Property of 2'-Iodo-6'-methoxyacetophenone

Chemical Property:

XLogP3:2.2
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:275.96473
Heavy Atom Count:12
Complexity:170

Purity/Quality:

95% ^*data from raw suppliers

1-(2-Iodo-6-methoxy-phenyl)-ethanone 95% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC(=O)C1=C(C=CC=C1I)OC

Technology Process of 2'-Iodo-6'-methoxyacetophenone

There total 4 articles about 2'-Iodo-6'-methoxyacetophenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 33844-23-4
1-(2-amino-6-methoxyphenyl)ethanone

: 380225-69-4
1-(2-iodo-6-methoxyphenyl)ethanone

Guidance literature:: With hydrogenchloride; potassium iodide; sodium nitrite; In water; acetic acid; at 60 ℃; for 1h;
DOI:10.1002/1099-0690(200109)2001:17<3247::AID-EJOC3247>3.0.CO;2-R

Reference yield:

: 60144-52-7
tert-butyl 3-methoxyphenylcarbamate

: 380225-69-4
1-(2-iodo-6-methoxyphenyl)ethanone

Guidance literature:: Multi-step reaction with 4 steps

1: 41 percent / tBuLi / tetrahydrofuran; pentane / 2.5 h / -20 °C

2: 66 percent / Dess-Martin periodinane / CH₂Cl₂ / 1 h / 0 °C

3: 94 percent / HCl / dioxane / 2.5 h / 20 °C

4: 88 percent / HCl; KI; NaNO₂ / acetic acid; H₂O / 1 h / 60 °C

With hydrogenchloride; tert.-butyl lithium; Dess-Martin periodane; potassium iodide; sodium nitrite; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; acetic acid; pentane; 4: Sandmayer reaction;
DOI:10.1002/1099-0690(200109)2001:17<3247::AID-EJOC3247>3.0.CO;2-R

Reference yield:

: 380225-70-7
1-[2-(tert-butyloxycarbonylamino)-6-methoxyphenyl]ethanol

: 380225-69-4
1-(2-iodo-6-methoxyphenyl)ethanone

Guidance literature:: Multi-step reaction with 3 steps

1: 66 percent / Dess-Martin periodinane / CH₂Cl₂ / 1 h / 0 °C

2: 94 percent / HCl / dioxane / 2.5 h / 20 °C

3: 88 percent / HCl; KI; NaNO₂ / acetic acid; H₂O / 1 h / 60 °C

With hydrogenchloride; Dess-Martin periodane; potassium iodide; sodium nitrite; In 1,4-dioxane; dichloromethane; water; acetic acid; 3: Sandmayer reaction;
DOI:10.1002/1099-0690(200109)2001:17<3247::AID-EJOC3247>3.0.CO;2-R