33844-23-4

Upstream product

• 53967-73-0 2-nitro-6-methoxybenzoic acid 
• 380225-70-7 1-[2-(tert-butyloxycarbonylamino)-6-methoxyphenyl]ethanol 
• 60144-52-7 tert-butyl 3-methoxyphenylcarbamate 
• 536-90-3 m-Anisidine 
• 75-05-8 acetonitrile 
• 53967-70-7 1-(2-methoxy-6-nitro-phenyl)-ethanone 
• 380225-72-9 1-[2-(tert-butyloxycarbonylamino)-6-methoxyphenyl]ethanone 

Downstream Products

• 56934-63-5 2'-Acetyl-3'-methoxyoxanilic acid ethyl ester 
• 380225-68-3 1-(2-bromo-6-methoxyphenyl)ethan-1-one 
• 380225-69-4 1-(2-iodo-6-methoxyphenyl)ethanone 
• 380225-79-6 7-acetoxy-1-(2-bromo-6-methoxyphenyl)non-8-ene-1,3-dione 
• 380225-75-2 7-acetoxy-1-(2-bromo-6-methoxyphenyl)-3-hydroxynon-8-en-1-one 
• 380225-76-3 7-acetoxy-1-(2-iodo-6-methoxyphenyl)-3-hydroxynon-8-en-1-one 
• 380225-80-9 7-acetoxy-1-(2-iodo-6-methoxyphenyl)non-8-ene-1,3-dione 
• 129473-16-1 2-(4-methylphenyl)-5-methoxy-4-quinolone 
• 1380698-91-8 2-[2-amino-6-(methyloxy)phenyl]-2-propanol 
• 1380698-92-9 N-[2-(1-hydroxy-1-methylethyl)-3-(methyloxy)phenyl]acetamide 
• 1429782-09-1 C₁₁H₁₀Cl₃NO₃ 
• 1432065-30-9 5-methoxy-4-methyl-3-phenylquinolin-2-one 
• 1432065-31-0 5-hydroxy-4-methyl-3-phenylquinolin-2-one 
• 1432065-29-6 C₁₇H₁₇NO₃ 

Relevant academic research and scientific papers

QUINAZOLINE DERIVATIVES AS PDE10A ENZYME INHIBITORS

This invention is directed to compounds, which are PDE10A enzyme inhibitors. The invention provides a pharmaceutical composition comprising a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. The pr

Trifluoromethyl-promoted homocamptothecins: Synthesis and biological activity

The homocamptothecin (hCPT) represents a new class of topoisomerase inhibitor which combines enhanced plasma stability and strong antitumor activity. Fluorine imparts desirable characteristics to drugs by modulating both the pharmacokinetics and pharmacodynamic properties of a drug. Therefore, in an attempt to improve the antitumor activity of homocamptothecins, seven new 7-trifluoromethylated homocamptothecin derivatives were prepared by proline-catalyzed Friedlander annulation. The antitumor activity in vitro and in vivo on cancer cell lines, and inhibitory properties of topoisomerase I-mediated DNA cleavage of compounds 6c and 8b were evaluated. Several of these trifluoromethylated hCPT derivatives (such as 6a, 6b and 6c) possessed higher in vitro antitumor activity than topotecan (TPT). Especially, the compound 6c showed effective in vivo antitumor activity comparable to that of TPT.

Practical synthesis of 2-(2-isopropylaminothiazol-4-yl)-7-methoxy-1H- quinolin-4-one: Key intermediate for the synthesis of potent HCV NS3 protease inhibitor BILN 2061

Herein we describe the development of an efficient, safe and practical process for the synthesis of 7-methoxy-2-(2-amino-4-thiazolyl)quinoline. Our new process allowed for a more convergent approach and eliminates the use of potentially dangerous reagents such as diazomethane used in the previous discovery approach. Georg Thieme Verlag Stuttgart.

A novel palladium-catalyzed domino Tsuji - Trost - Heck process for the synthesis of tetrahydroanthracenes

A novel type of palladium-catalyzed domino reaction is described combining Tsuji - Trost and Heck reactions. This method allows efficient access to tetrahydroanthracene derivatives 1 in up to 89% isolated yield in a one-pot process starting from the diket

Quinolyloxyacetamides

Quinoline derivatives of formula: STR1 in which either R 1 denotes trifluoromethyl, R 2 and R 3 form, together with the nitrogen atom to which they are attached, morpholino and R 4 denotes a 4-methylphenyl, 4-chlorophenyl, 2-, 3- or 4-fluorophenyl, 4-meth

Process for the preparation of optionally substituted 1,2,3,5-tetrahydroimidazo[2,1-b]quinazolin-2-ones

A new process has been developed for the synthesis of optionally substituted 1,2,3,5-tetrahydroimidazo[2,1-b]quinazolin-2-ones. In particular, the process is particularly adaptable for the preparation of the 5,6-disubstituted compounds, e.g., 5,6-dimethyl-1,2,3,5-tetrahydroimidazo-[2,1-b]quinazolin-2-one. The compounds so prepared are useful as blood platelet anti-aggregative and/or antihypertensive agents in mammals, including humans.