(E)-tert-butyl 3-(4-((6-methoxy-2-(4-methoxyphenyl)benzo-[b]thiophen-3-yl)oxy)phenyl)acrylate

Base Information

• Chemical Name: (E)-tert-butyl 3-(4-((6-methoxy-2-(4-methoxyphenyl)benzo-[b]thiophen-3-yl)oxy)phenyl)acrylate
• CAS No.: 1622308-91-1
• Molecular Formula: C₂₉H₂₈O₅S
• Molecular Weight: 488.604

Synonyms:(E)-tert-butyl 3-(4-((6-methoxy-2-(4-methoxyphenyl)benzo-[b]thiophen-3-yl)oxy)phenyl)acrylate

Chemical Property of (E)-tert-butyl 3-(4-((6-methoxy-2-(4-methoxyphenyl)benzo-[b]thiophen-3-yl)oxy)phenyl)acrylate

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of (E)-tert-butyl 3-(4-((6-methoxy-2-(4-methoxyphenyl)benzo-[b]thiophen-3-yl)oxy)phenyl)acrylate

There total 5 articles about (E)-tert-butyl 3-(4-((6-methoxy-2-(4-methoxyphenyl)benzo-[b]thiophen-3-yl)oxy)phenyl)acrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

tert-Butyl acrylate (1663-39-4,25232-27-3) + 3-(4-bromophenoxy)-6-methoxy-2-(4-methoxyphenyl)benzo[b]thiophene (1622308-87-5) → (E)-tert-butyl 3-(4-((6-methoxy-2-(4-methoxyphenyl)benzo-[b]thiophen-3-yl)oxy)phenyl)acrylate (1622308-91-1)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; triethylamine; In N,N-dimethyl-formamide; at 120 ℃; for 1h; Microwave irradiation;

Reference yield:

3-(4-bromophenoxy)-6-methoxy-2-(4-methoxyphenyl)benzo[b]thiophene 1-oxide (1622308-83-1) → (E)-tert-butyl 3-(4-((6-methoxy-2-(4-methoxyphenyl)benzo-[b]thiophen-3-yl)oxy)phenyl)acrylate (1622308-91-1)

Guidance literature:

Multi-step reaction with 2 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 0.5 h / 0 °C

2: bis-triphenylphosphine-palladium(II) chloride; triethylamine / N,N-dimethyl-formamide / 1 h / 120 °C / Microwave irradiation

With bis-triphenylphosphine-palladium(II) chloride; lithium aluminium tetrahydride; triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield:

2-(4'-methoxyphenyl)-6-methoxybenzothiophene (63675-74-1) → (E)-tert-butyl 3-(4-((6-methoxy-2-(4-methoxyphenyl)benzo-[b]thiophen-3-yl)oxy)phenyl)acrylate (1622308-91-1)

Guidance literature:

Multi-step reaction with 5 steps

1.1: N-Bromosuccinimide / tetrahydrofuran / 3 h / 0 - 20 °C

2.1: trifluoroacetic acid / dichloromethane / 0.17 h / 20 °C

2.2: 1.5 h / 20 °C

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.17 h / 20 °C

3.2: 18 h / 80 °C

4.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.5 h / 0 °C

5.1: bis-triphenylphosphine-palladium(II) chloride; triethylamine / N,N-dimethyl-formamide / 1 h / 120 °C / Microwave irradiation

With bis-triphenylphosphine-palladium(II) chloride; N-Bromosuccinimide; lithium aluminium tetrahydride; sodium hydride; triethylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; mineral oil;

upstream raw materials:

3-(4-bromophenoxy)-6-methoxy-2-(4-methoxyphenyl)benzo[b]thiophene 1-oxide

tert-Butyl acrylate

3-(4-bromophenoxy)-6-methoxy-2-(4-methoxyphenyl)benzo[b]thiophene

2-(4'-methoxyphenyl)-6-methoxybenzothiophene

Downstream raw materials:

3-(4-((6-hydroxy-2-(4-hydroxyphenyl)-benzo-[b]thiophen-3-yl)oxy)phenyl)propanoic acid

tert-butyl 3-(4-((6-methoxy-2-(4-methoxyphenyl)benzo[b]thiophen-3-yl)oxy)phenyl)propanoate

(E)-3-(4-((6-hydroxy-2-(4-hydroxyphenyl)benzo[b]thiophen-3-yl)-oxy)phenyl)-N-(2-hydroxyethyl)acrylamide

(E)-3-(4-((6-hydroxy-2-(4-hydroxyphenyl)-benzo[b]thiophen-3-yl)oxy)phenyl)acrylamide

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