N-(5-chloropyridin-2-yl)acetamide

Base Information

• Chemical Name: N-(5-chloropyridin-2-yl)acetamide
• CAS No.: 45965-30-8
• Molecular Formula: C7H7 Cl N2 O
• Molecular Weight: 170.598
• DSSTox Substance ID: DTXSID60355381
• Nikkaji Number: J1.974.189C
• Wikidata: Q82134244
• ChEMBL ID: CHEMBL2425110
• Mol file: 45965-30-8.mol

Synonyms:N-(5-chloropyridin-2-yl)acetamide;45965-30-8;2-acetamido-5-chloropyridine;2-Acetylamino-5-chloropyridine;CHEMBL2425110;n-(5-chloro-2-pyridinyl)acetamide;BAS 02242076;SCHEMBL1431137;DTXSID60355381;HMS1672O04;BDBM50440380;MFCD02577036;STK079158;AKOS000626952;CS-0191704;FT-0756644;E89633;Zopiclone-M/artifact (amino-chloro-pyridine) AC;Z71484766

Chemical Property of N-(5-chloropyridin-2-yl)acetamide

Chemical Property:

• PSA: 41.99000
• LogP: 1.76640
• XLogP3: 1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 170.0246905
• Heavy Atom Count: 11
• Complexity: 151

Purity/Quality:

95% ^*data from raw suppliers

Acetamide,N-(5-chloro-2-pyridinyl)- 95 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(=O)NC1=NC=C(C=C1)Cl

Technology Process of N-(5-chloropyridin-2-yl)acetamide

There total 8 articles about N-(5-chloropyridin-2-yl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

disodium hydrogenphosphate + N-(2-pyridyl)acetamide (5231-96-9) → N-(5-chloro-pyridin-2-yl)acetamide (45965-30-8)

Guidance literature:

With chlorine; In dichloromethane; water;

Reference yield: 87.0%

5-chloro-2-pyridylamine (1072-98-6) + acetonitrile (75-05-8,26809-02-9) → N-(5-chloro-pyridin-2-yl)acetamide (45965-30-8)

Guidance literature:

With phosphoric acid; sodium nitrite; at 10 - 20 ℃;

DOI:10.1007/s11172-016-1583-9

Reference yield: 82.0%

5-chloro-2-pyridylamine (1072-98-6) + N,N-dimethyl acetamide (127-19-5,116057-81-9) → N-(5-chloro-pyridin-2-yl)acetamide (45965-30-8)

Guidance literature:

N,N-dimethyl acetamide; With 1,1'-carbonyldiimidazole; at 120 - 125 ℃; for 0.5h; Inert atmosphere;

5-chloro-2-pyridylamine; at 60 - 65 ℃; Microwave irradiation; Inert atmosphere;

DOI:10.1016/j.tetlet.2015.04.077

upstream raw materials:

5-chloro-2-pyridylamine

acetic anhydride

phenyl isocyanate

N-Fluoro-3-chloropyridinium triflate