N-<(1,1-dimethylethoxy)carbonyl>-N-(phenylmethyl)glycyl-L-serine methyl ester

Base Information

Chemical Name:N-<(1,1-dimethylethoxy)carbonyl>-N-(phenylmethyl)glycyl-L-serine methyl ester
CAS No.:149648-96-4
Molecular Formula:C₁₈H₂₆N₂O₆
Molecular Weight:366.414
Hs Code.:

Synonyms:N-<(1,1-dimethylethoxy)carbonyl>-N-(phenylmethyl)glycyl-L-serine methyl ester

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Chemical Property of N-<(1,1-dimethylethoxy)carbonyl>-N-(phenylmethyl)glycyl-L-serine methyl ester

Chemical Property:

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Technology Process of N-<(1,1-dimethylethoxy)carbonyl>-N-(phenylmethyl)glycyl-L-serine methyl ester

There total 1 articles about N-<(1,1-dimethylethoxy)carbonyl>-N-(phenylmethyl)glycyl-L-serine methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5680-80-8
methyl (2S)-2-amino-3-hydroxypropanoate hydrochloride

: 76315-01-0
N-benzyl-N-(tert-butoxycarbonyl)glycine

: 149648-96-4
N-<(1,1-dimethylethoxy)carbonyl>-N-(phenylmethyl)glycyl-L-serine methyl ester

Guidance literature:: With 2,3,4,5,6-pentafluorophenol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; Yield given. Multistep reaction; 1.) dichloromethane, RT, 3 h, 2.) dichloromethane, RT, 20 h;
DOI:10.1021/jm00067a004

Reference yield:

: 149648-96-4
N-<(1,1-dimethylethoxy)carbonyl>-N-(phenylmethyl)glycyl-L-serine methyl ester

: (R)-4-[2-(3,4-Dichloro-phenyl)-acetyl]-3-formyl-piperazine-1-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) SOCl₂, 2.) aq. NH₃ / 1.) methanol, RT, 2 h, 2.) methanol

2: 91 percent / LiAlH₄ / tetrahydrofuran / 1.5 h / Heating

3: 56 percent / H₂ / 5percent Pd/C / ethanol / 760 Torr

4: 96 percent / acetonitrile / 0.5 h / Ambient temperature

5: 1.) 1,1'-carbonyldiimidazole, 3.) LiOH

6: 1.) dimethyl sulfoxide, oxalyl chloride, 2.) N-methylmorpholine / 1.) dichloromethane, -68 deg C, 2.5 h, 2.) dichloromethane, -20 deg C, 45 min

With 4-methyl-morpholine; lithium hydroxide; ammonium hydroxide; lithium aluminium tetrahydride; thionyl chloride; oxalyl dichloride; hydrogen; dimethyl sulfoxide; 1,1'-carbonyldiimidazole; palladium on activated charcoal; In tetrahydrofuran; ethanol; acetonitrile;
DOI:10.1021/jm00067a004

Reference yield:

: 149648-96-4
N-<(1,1-dimethylethoxy)carbonyl>-N-(phenylmethyl)glycyl-L-serine methyl ester

: (R)-methyl 4-(2-(3,4-dichlorophenyl)acetyl)-3-(pyrrolidin-1-ylmethyl)piperazine-1-carboxylate

Guidance literature:: Multi-step reaction with 7 steps

1: 1.) SOCl₂, 2.) aq. NH₃ / 1.) methanol, RT, 2 h, 2.) methanol

2: 91 percent / LiAlH₄ / tetrahydrofuran / 1.5 h / Heating

3: 56 percent / H₂ / 5percent Pd/C / ethanol / 760 Torr

4: 96 percent / acetonitrile / 0.5 h / Ambient temperature

5: 1.) 1,1'-carbonyldiimidazole, 3.) LiOH

6: 1.) dimethyl sulfoxide, oxalyl chloride, 2.) N-methylmorpholine / 1.) dichloromethane, -68 deg C, 2.5 h, 2.) dichloromethane, -20 deg C, 45 min

7: HCl, NaBH₃CN, 3A molecular sieves / methanol / 18 h / Ambient temperature

With 4-methyl-morpholine; hydrogenchloride; lithium hydroxide; ammonium hydroxide; lithium aluminium tetrahydride; thionyl chloride; oxalyl dichloride; 3 A molecular sieve; hydrogen; sodium cyanoborohydride; dimethyl sulfoxide; 1,1'-carbonyldiimidazole; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; acetonitrile;
DOI:10.1021/jm00067a004