(2'S,3S,4'R,5'R)-1,2-dihydro-2'-(2-methoxy-2-methylpropyl)-2-oxo-5'-[[(2R)-2-[(phenylmethoxy)carbonyl]-1-pyrrolidinyl]carbonyl]spiro[3H-indole-3,3'-pyrrolidine]-4'-carboxylic acid ethyl ester

Base Information

Chemical Name:(2'S,3S,4'R,5'R)-1,2-dihydro-2'-(2-methoxy-2-methylpropyl)-2-oxo-5'-[[(2R)-2-[(phenylmethoxy)carbonyl]-1-pyrrolidinyl]carbonyl]spiro[3H-indole-3,3'-pyrrolidine]-4'-carboxylic acid ethyl ester
CAS No.:282735-71-1
Molecular Formula:C₃₂H₃₉N₃O₇
Molecular Weight:577.678
Hs Code.:

(2'S,3S,4'R,5'R)-1,2-dihydro-2'-(2-methoxy-2-methylpropyl)-2-oxo-5'-[[(2R)-2-[(phenylmethoxy)carbonyl]-1-pyrrolidinyl]carbonyl]spiro[3H-indole-3,3'-pyrrolidine]-4'-carboxylic acid ethyl ester

Synonyms:(2'S,3S,4'R,5'R)-1,2-dihydro-2'-(2-methoxy-2-methylpropyl)-2-oxo-5'-[[(2R)-2-[(phenylmethoxy)carbonyl]-1-pyrrolidinyl]carbonyl]spiro[3H-indole-3,3'-pyrrolidine]-4'-carboxylic acid ethyl ester

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Chemical Property of (2'S,3S,4'R,5'R)-1,2-dihydro-2'-(2-methoxy-2-methylpropyl)-2-oxo-5'-[[(2R)-2-[(phenylmethoxy)carbonyl]-1-pyrrolidinyl]carbonyl]spiro[3H-indole-3,3'-pyrrolidine]-4'-carboxylic acid ethyl ester

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Technology Process of (2'S,3S,4'R,5'R)-1,2-dihydro-2'-(2-methoxy-2-methylpropyl)-2-oxo-5'-[[(2R)-2-[(phenylmethoxy)carbonyl]-1-pyrrolidinyl]carbonyl]spiro[3H-indole-3,3'-pyrrolidine]-4'-carboxylic acid ethyl ester

There total 8 articles about (2'S,3S,4'R,5'R)-1,2-dihydro-2'-(2-methoxy-2-methylpropyl)-2-oxo-5'-[[(2R)-2-[(phenylmethoxy)carbonyl]-1-pyrrolidinyl]carbonyl]spiro[3H-indole-3,3'-pyrrolidine]-4'-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 64472-06-6
(R)-proline benzyl ester

: 473896-06-9
(2'S,3'S,4'R,5'R)-2'-(2-Methoxy-2-methyl-propyl)-2-oxo-1,2-dihydro-spiro[indole-3,3'-pyrrolidine]-4',5'-dicarboxylic acid 4'-ethyl ester

: 282735-71-1
(2'S,3S,4'R,5'R)-1,2-dihydro-2'-(2-methoxy-2-methylpropyl)-2-oxo-5'-[[(2R)-2-[(phenylmethoxy)carbonyl]-1-pyrrolidinyl]carbonyl]spiro[3H-indole-3,3'-pyrrolidine]-4'-carboxylic acid ethyl ester

Guidance literature:: With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; In acetonitrile;
DOI:10.1021/ja001133n

Reference yield:

: 21728-28-9,67502-96-9
(E)-(2-oxo-1,2-dihydroindol-3-ylidene)acetic acid ethyl ester

: 282735-71-1
(2'S,3S,4'R,5'R)-1,2-dihydro-2'-(2-methoxy-2-methylpropyl)-2-oxo-5'-[[(2R)-2-[(phenylmethoxy)carbonyl]-1-pyrrolidinyl]carbonyl]spiro[3H-indole-3,3'-pyrrolidine]-4'-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 3 Angstroem molecular sieves / toluene / Heating

2: 99 percent / H₂; PdCl₂ / tetrahydrofuran; ethanol / 36 h / 3620.04 Torr

3: 74 percent / [benzotriazol-1-yloxy-tris(dimethylamino)phosphonium]PF₆; triethylamine / acetonitrile / 8 h / 20 °C

With 3 A molecular sieve; hydrogen; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; palladium dichloride; In tetrahydrofuran; ethanol; toluene; acetonitrile;
DOI:10.1016/S0040-4020(02)00630-0

Reference yield:

: 282735-67-5
(3S,3'S,4'R,6'S,8'R,8'aR)-1,2,3',4',8',8a'-hexahydro-6'-(2-methoxy-2-methylpropyl)-1',2-dioxo-3',4'-diphenylspiro[3H-indole-3,7'(6'H)-[1H]pyrrolo[2,1-c][1,4]oxazine]-8'-carboxylic acid ethyl ester

: 282735-71-1
(2'S,3S,4'R,5'R)-1,2-dihydro-2'-(2-methoxy-2-methylpropyl)-2-oxo-5'-[[(2R)-2-[(phenylmethoxy)carbonyl]-1-pyrrolidinyl]carbonyl]spiro[3H-indole-3,3'-pyrrolidine]-4'-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 99 percent / H₂; PdCl₂ / tetrahydrofuran; ethanol / 36 h / 3620.04 Torr

2: 74 percent / [benzotriazol-1-yloxy-tris(dimethylamino)phosphonium]PF₆; triethylamine / acetonitrile / 8 h / 20 °C

With hydrogen; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; palladium dichloride; In tetrahydrofuran; ethanol; acetonitrile;
DOI:10.1016/S0040-4020(02)00630-0