((3-ethynyl-6-methoxy-1,2-phenylene)bis(oxy))bis(tert-butyldimethylsilane)

Base Information

Chemical Name:((3-ethynyl-6-methoxy-1,2-phenylene)bis(oxy))bis(tert-butyldimethylsilane)
CAS No.:1363603-18-2
Molecular Formula:C₂₁H₃₆O₃Si₂
Molecular Weight:392.686
Hs Code.:

Synonyms:((3-ethynyl-6-methoxy-1,2-phenylene)bis(oxy))bis(tert-butyldimethylsilane)

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Chemical Property of ((3-ethynyl-6-methoxy-1,2-phenylene)bis(oxy))bis(tert-butyldimethylsilane)

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Technology Process of ((3-ethynyl-6-methoxy-1,2-phenylene)bis(oxy))bis(tert-butyldimethylsilane)

There total 3 articles about ((3-ethynyl-6-methoxy-1,2-phenylene)bis(oxy))bis(tert-butyldimethylsilane) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 109971-66-6
2,3-bis<(tert-butyldimethylsilyl)oxy>-4-methoxybenzaldehyde

: 18107-18-1
diazomethyl-trimethyl-silane

: 1363603-18-2
((3-ethynyl-6-methoxy-1,2-phenylene)bis(oxy))bis(tert-butyldimethylsilane)

Guidance literature:: diazomethyl-trimethyl-silane; With lithium diisopropyl amide; In tetrahydrofuran; hexane; at -78 ℃; for 1h; Inert atmosphere;

2,3-bis<(tert-butyldimethylsilyl)oxy>-4-methoxybenzaldehyde; In tetrahydrofuran; hexane; at -78 - 20 ℃; for 2h; Inert atmosphere;
DOI:10.1016/j.bmc.2012.01.010

Reference yield:

: 2103-57-3
2,3,4-trimethoxybenzaldehyde

: 1363603-18-2
((3-ethynyl-6-methoxy-1,2-phenylene)bis(oxy))bis(tert-butyldimethylsilane)

Guidance literature:: Multi-step reaction with 3 steps

1.1: boron trichloride / dichloromethane / 20 h / 20 °C / Inert atmosphere

2.1: dmap; triethylamine / N,N-dimethyl-formamide / 18 h / 20 °C / Inert atmosphere

3.1: lithium diisopropyl amide / tetrahydrofuran; hexane / 1 h / -78 °C / Inert atmosphere

3.2: 2 h / -78 - 20 °C / Inert atmosphere

With dmap; boron trichloride; triethylamine; lithium diisopropyl amide; In tetrahydrofuran; hexane; dichloromethane; N,N-dimethyl-formamide; 3.2: Colvin rearrangement;
DOI:10.1016/j.bmc.2012.01.010

Reference yield:

: 4055-69-0
2,3-dihydroxy-4-methoxybenzaldehyde

: 1363603-18-2
((3-ethynyl-6-methoxy-1,2-phenylene)bis(oxy))bis(tert-butyldimethylsilane)

Guidance literature:: Multi-step reaction with 2 steps

1.1: dmap; triethylamine / N,N-dimethyl-formamide / 18 h / 20 °C / Inert atmosphere

2.1: lithium diisopropyl amide / tetrahydrofuran; hexane / 1 h / -78 °C / Inert atmosphere

2.2: 2 h / -78 - 20 °C / Inert atmosphere

With dmap; triethylamine; lithium diisopropyl amide; In tetrahydrofuran; hexane; N,N-dimethyl-formamide; 2.2: Colvin rearrangement;
DOI:10.1016/j.bmc.2012.01.010