N-cyclopentyl-5-(3,5-dimethylisoxazol-4-yl)-2-methoxy-N-methylbenzenesulfonamide

Base Information

Chemical Name:N-cyclopentyl-5-(3,5-dimethylisoxazol-4-yl)-2-methoxy-N-methylbenzenesulfonamide
CAS No.:1355555-29-1
Molecular Formula:C₁₈H₂₄N₂O₄S
Molecular Weight:364.466
Hs Code.:

Synonyms:N-cyclopentyl-5-(3,5-dimethylisoxazol-4-yl)-2-methoxy-N-methylbenzenesulfonamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-cyclopentyl-5-(3,5-dimethylisoxazol-4-yl)-2-methoxy-N-methylbenzenesulfonamide

Chemical Property:

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Technology Process of N-cyclopentyl-5-(3,5-dimethylisoxazol-4-yl)-2-methoxy-N-methylbenzenesulfonamide

There total 4 articles about N-cyclopentyl-5-(3,5-dimethylisoxazol-4-yl)-2-methoxy-N-methylbenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 1355554-31-2
N-cyclopentyl-5-(3,5-dimethylisoxazol-4-yl)-2-methoxybenzenesulfonamide

: 74-88-4
methyl iodide

: 1355555-29-1
N-cyclopentyl-5-(3,5-dimethylisoxazol-4-yl)-2-methoxy-N-methylbenzenesulfonamide

Guidance literature:: N-cyclopentyl-5-(3,5-dimethylisoxazol-4-yl)-2-methoxybenzenesulfonamide; With sodium hydride; In N,N-dimethyl-formamide; at 0 ℃; for 0.5h;

methyl iodide; In N,N-dimethyl-formamide; at 20 ℃; for 1h; Inert atmosphere;
DOI:10.1021/jm201283q

Reference yield:

: 915930-21-1
5-bromo-N-cyclopentyl-2-methoxybenzenesulfonamide

: 1355555-29-1
N-cyclopentyl-5-(3,5-dimethylisoxazol-4-yl)-2-methoxy-N-methylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate / 1,4-dioxane; water / 1 h / 100 °C

2.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 °C

2.2: 1 h / 20 °C / Inert atmosphere

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium hydride; potassium carbonate; In 1,4-dioxane; water; N,N-dimethyl-formamide; 1.1: Suzuki coupling;
DOI:10.1021/jm201283q

Reference yield:

: 23095-05-8
5-bromo-2-methoxybenzenesulfonyl chloride

: 1355555-29-1
N-cyclopentyl-5-(3,5-dimethylisoxazol-4-yl)-2-methoxy-N-methylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: bis(isopropyl)ethylamine / dichloromethane / 20 °C / Inert atmosphere

2.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate / 1,4-dioxane; water / 1 h / 100 °C

3.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 °C

3.2: 1 h / 20 °C / Inert atmosphere

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; bis(isopropyl)ethylamine; sodium hydride; potassium carbonate; In 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide; 2.1: Suzuki coupling;
DOI:10.1021/jm201283q