1596364-73-6

Basic information

• Product Name: (1S,2R,3S,4R)-methyl 4-((5-(benzo[d]thiazol-2-yl)-2-(methylthio)pyrimidin-4-yl)amino)-2-((tert-butyldiphenylsilyl)oxy)-3-methoxycyclopentanecarboxylate
• Synonyms: (1S,2R,3S,4R)-methyl 4-((5-(benzo[d]thiazol-2-yl)-2-(methylthio)pyrimidin-4-yl)amino)-2-((tert-butyldiphenylsilyl)oxy)-3-methoxycyclopentanecarboxylate
• CAS NO: 1596364-73-6
• Molecular Weight: 684.955
• Mol File: 1596364-73-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (1S,2R,3S,4R)-methyl 4-((5-(benzo[d]thiazol-2-yl)-2-(methylthio)pyrimidin-4-yl)amino)-2-((tert-butyldiphenylsilyl)oxy)-3-methoxycyclopentanecarboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: (1S,2R,3S,4R)-methyl 4-((5-(benzo[d]thiazol-2-yl)-2-(methylthio)pyrimidin-4-yl)amino)-2-((tert-butyldiphenylsilyl)oxy)-3-methoxycyclopentanecarboxylate(1596364-73-6)
• EPA Substance Registry System: (1S,2R,3S,4R)-methyl 4-((5-(benzo[d]thiazol-2-yl)-2-(methylthio)pyrimidin-4-yl)amino)-2-((tert-butyldiphenylsilyl)oxy)-3-methoxycyclopentanecarboxylate(1596364-73-6)

Safety Data

• Hazardous Substances Data: 1596364-73-6(Hazardous Substances Data)

Upstream product

• 111079-19-7 4-chloro-5-iodo-2-(methylsulfanyl)pyrimidine 
• 76510-61-7 5-iodo-4-hydroxy-6-methyl-2-methylthiopyrimidine 
• 5751-20-2 2-Methylthiouracil 
• 95-16-9 1,3-Benzothiazole 
• 1596364-72-5 (1S,2R,3S,4R)-methyl 2-((tert-butyldiphenylsilyl)oxy)-4-((5-iodo-2-(methylthio)pyrimidin-4-yl)amino)-3-methoxycyclopentanecarboxylate 
• 1596364-71-4 (1S,2R,3S,4R)-methyl 4-amino-2-((tert-butyldiphenylsilyl)oxy)-3-methoxycyclopentanecarboxylate 
• 1596364-70-3 (1S,2R,3S,4R)-methyl 2-((tert-butyldiphenylsilyl)oxy)-4-(1,3-dioxoisoindolin-2-yl)-3-methoxycyclopentanecarboxylate 
• 1596364-69-0 (1S,2R,3S,4R)-2-((tert-butyldiphenylsilyl)oxy)-4-(1,3-dioxoisoindolin-2-yl)-3-methoxycyclopentanecarboxylic acid 
• 1596364-68-9 2-((1R,2S,3R,4R)-3-((tert-butyldiphenylsilyl)oxy)-4-(hydroxymethyl)-2-methoxycyclopentyl)isoindoline-1,3-dione 
• 1596364-67-8 2-((1R,2S,3R,4R)-4-(((tert-butyldimethylsilyl)oxy)methyl)-3-((tert-butyldiphenylsilyl)oxy)-2-methoxycyclopentyl)isoindoline-1,3-dione 
• 1596364-66-7 2-((1R,2S,3R,4R)-4-(((tert-butyldimethylsilyl)oxy)methyl)-3-hydroxy-2-methoxycyclopentyl)isoindoline-1,3-dione 
• 1208988-85-5 2-((6aR,8R,9S,9aR)-2,2,4,4-tetraisopropyl-9-methoxyhexahydrocyclopenta[f][1,3,5,2,4]trioxadisilocin-8-yl)isoindoline-1,3-dione 
• 1596364-65-6 2-(1R,2S,3R,4R)-3-hydroxy-4-(hydroxymethyl)-2-methoxycyclopentylisoindoline-1,3-dione 

Downstream Products

• 1596364-74-7 (1S,2R,3S,4R)-methyl 4-((2-amino-5-(benzo[d]thiazol-2-yl)pyrimidin-4-yl)amino)-2-((tert-butyldiphenylsilyl)oxy)-3-methoxycyclopentanecarboxylate 
• 1596364-75-8 (1S,2R,3S,4R)-methyl 4-((5-(benzo[d]thiazol-2-yl)-2-((2,6-dimethylpyridin-4-yl)amino)pyrimidin-4-yl)amino)-2-((tert-butyldiphenylsilyl)oxy)-3-methoxycyclopentanecarboxylate 
• 1596364-76-9 2-((1S,2R,3S,4R)-4-((5-(benzo[d]thiazol-2-yl)-2-(methylthio)pyrimidin-4-yl)amino)-2-((tert-butyldiphenylsilyl)oxy)-3-methoxycyclopentyl)propan-2-ol 

Relevant articles and documents

INHIBITORS OF IRAK4 ACTIVITY

The present invention relates to compounds which modulate interleukin-l (IL-1 ) receptor-associated kinase 4 (IRAK4) and are useful in the prevention or treatment of inflammatory, cell proliferative and immune-related conditions and diseases. Specifically, provided herein are inhibitors of IRAK4 of Formula I and pharmaceutical compositions comprising such inhibitors, as well as methods therewith for treating IRAK4-mediated or -associated conditions or diseases.