(S)-1-((R)-2-Amino-3,3-diphenyl-propionyl)-pyrrolidine-2-carboxylic acid 4-cyano-benzylamide

Base Information

• Chemical Name: (S)-1-((R)-2-Amino-3,3-diphenyl-propionyl)-pyrrolidine-2-carboxylic acid 4-cyano-benzylamide
• CAS No.: 1026961-32-9
• Molecular Formula: C₂₈H₂₈N₄O₂
• Molecular Weight: 452.556
• Mol file: 1026961-32-9.mol

Synonyms:(S)-1-((R)-2-Amino-3,3-diphenyl-propionyl)-pyrrolidine-2-carboxylic acid 4-cyano-benzylamide

Chemical Property of (S)-1-((R)-2-Amino-3,3-diphenyl-propionyl)-pyrrolidine-2-carboxylic acid 4-cyano-benzylamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-1-((R)-2-Amino-3,3-diphenyl-propionyl)-pyrrolidine-2-carboxylic acid 4-cyano-benzylamide

There total 6 articles about (S)-1-((R)-2-Amino-3,3-diphenyl-propionyl)-pyrrolidine-2-carboxylic acid 4-cyano-benzylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

{(R)-1-[(S)-2-(4-Cyano-benzylcarbamoyl)-pyrrolidine-1-carbonyl]-2,2-diphenyl-ethyl}-carbamic acid tert-butyl ester → (S)-1-((R)-2-Amino-3,3-diphenyl-propionyl)-pyrrolidine-2-carboxylic acid 4-cyano-benzylamide (1026961-32-9)

Guidance literature:

With trifluoroacetic acid; In dichloromethane;

DOI:10.1016/S0960-894X(02)00093-8

Reference yield:

4-cyanobenzylamine hydrochloride (15996-76-6) → (S)-1-((R)-2-Amino-3,3-diphenyl-propionyl)-pyrrolidine-2-carboxylic acid 4-cyano-benzylamide (1026961-32-9)

Guidance literature:

Multi-step reaction with 2 steps

1: EDC; HOBT; Et₃N / dimethylformamide / 20 °C

2: HCl / ethyl acetate / 20 °C

With hydrogenchloride; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; In ethyl acetate; N,N-dimethyl-formamide;

DOI:10.1021/jm030025j

Reference yield:

N-(tert-butyloxycarbonyl)-D-3,3-diphenylalanyl-L-proline (138971-65-0) → (S)-1-((R)-2-Amino-3,3-diphenyl-propionyl)-pyrrolidine-2-carboxylic acid 4-cyano-benzylamide (1026961-32-9)

Guidance literature:

Multi-step reaction with 2 steps

1: EDC; HOBT; Et₃N / dimethylformamide / 20 °C

2: HCl / ethyl acetate / 20 °C

With hydrogenchloride; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; In ethyl acetate; N,N-dimethyl-formamide;

DOI:10.1021/jm030025j

upstream raw materials:

4-cyanobenzylamine hydrochloride

N-(tert-butyloxycarbonyl)-D-3,3-diphenylalanyl-L-proline

para-methylbenzonitrile

4-cyanobenzyl bromide