5-Fluoro-2-methylpyridine 1-oxide

Base Information

Chemical Name:5-Fluoro-2-methylpyridine 1-oxide
CAS No.:45673-79-8
Molecular Formula:C₆H₆FNO
Molecular Weight:127.118
Hs Code.:2933399090
DSSTox Substance ID:DTXSID30599235
Wikidata:Q82495110
Mol file:45673-79-8.mol

Synonyms:5-Fluoro-2-methylpyridine 1-oxide;45673-79-8;5-fluoro-2-methyl-1-oxidopyridin-1-ium;5-Fluoro-2-methylpyridine1-oxide;Pyridine, 5-fluoro-2-methyl-, 1-oxide;5-FLUORO-2-METHYLPYRIDIN-1-IUM-1-OLATE;Pyridine, 5-fluoro-2-methyl-, 1-oxide (9CI);5-Fluoro-2-picoline N-oxide;5-Fluoro-2-picoline-N-oxide;SCHEMBL5253733;DTXSID30599235;RIUFOUJMGXWZCJ-UHFFFAOYSA-N;AC6175;MFCD12828023;AKOS032961549;SY042540;DB-083236;5-Fluoro-2-methyl-1-oxo-1lambda~5~-pyridine;A15578

Suppliers and Price of 5-Fluoro-2-methylpyridine 1-oxide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Chemenu
5-Fluoro-2-methylpyridine1-Oxide 95%
1g
$ 541.00

Chemcia Scientific
5-Fluoro-2-methyl-pyridine1-oxide 95%
5 G
$ 685.00

AK Scientific
5-Fluoro-2-methylpyridine1-oxide
1g
$ 937.00

Total 11 raw suppliers

Chemical Property of 5-Fluoro-2-methylpyridine 1-oxide

Chemical Property:

Boiling Point:282.7±20.0 °C(Predicted)
PKA:0.56±0.10(Predicted)
PSA：25.46000
Density:1.15±0.1 g/cm3(Predicted)
LogP:1.56260
XLogP3:0.4
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:0
Exact Mass:127.043341977
Heavy Atom Count:9
Complexity:99.1

Purity/Quality:

97% ^*data from raw suppliers

5-Fluoro-2-methylpyridine1-Oxide 95% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=[N+](C=C(C=C1)F)[O-]

Technology Process of 5-Fluoro-2-methylpyridine 1-oxide

There total 3 articles about 5-Fluoro-2-methylpyridine 1-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 31181-53-0
2‐methyl‐5‐fluoropyridine

: 45673-79-8
2‐methyl‐5‐fluoropyridine 1‐oxide

Guidance literature:: With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 0 - 25 ℃; for 48h;
DOI:10.1021/ml500353p

Reference yield: 22.0%

: 45673-79-8
2‐methyl‐5‐fluoropyridine 1‐oxide

Guidance literature:

Reference yield:

: 80287-53-2,3430-14-6
5-Amino-2-methylpyridine

: 45673-79-8
2‐methyl‐5‐fluoropyridine 1‐oxide

Guidance literature:: Multi-step reaction with 2 steps

1: 1) NaNO₂, conc. HCl, 2) hexafluorophosphoric acid / 1) H₂O, -5 to 0 deg C, 5 min

2: m-chloroperbenzoic acid / CH₂Cl₂ / 16 h / Ambient temperature

With hydrogenchloride; hexafluorophosphoric acid; 3-chloro-benzenecarboperoxoic acid; sodium nitrite; In dichloromethane;
DOI:10.1021/jm00128a046