Pyridine, 4-chloro-5-fluoro-2-methyl-, 1-oxide

Base Information

Chemical Name:Pyridine, 4-chloro-5-fluoro-2-methyl-, 1-oxide
CAS No.:113209-89-5
Molecular Formula:C₆H₅ClFNO
Molecular Weight:161.563
Hs Code.:
Mol file:113209-89-5.mol

Synonyms:113209-89-5;Pyridine, 4-chloro-5-fluoro-2-methyl-, 1-oxide;4-Chloro-5-fluoro-2-methylpyridine, N-oxide;4-chloro-5-fluoro-2-methyl-1-oxidopyridin-1-ium;SCHEMBL3658841;XVWMFVTWZZSTTN-UHFFFAOYSA-N;4-Chloro-5-fluoro-2-picoline-N-oxide;A15134;4-chloro-5-fluoro-2-methylpyridin-1-ium-1-olate

Suppliers and Price of Pyridine, 4-chloro-5-fluoro-2-methyl-, 1-oxide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 3 raw suppliers

Chemical Property of Pyridine, 4-chloro-5-fluoro-2-methyl-, 1-oxide

Chemical Property:

PSA：25.46000
LogP:2.21600
XLogP3:1
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:0
Exact Mass:161.0043696
Heavy Atom Count:10
Complexity:124

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=CC(=C(C=[N+]1[O-])F)Cl

Technology Process of Pyridine, 4-chloro-5-fluoro-2-methyl-, 1-oxide

There total 4 articles about Pyridine, 4-chloro-5-fluoro-2-methyl-, 1-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 113209-88-4
5-fluoro-2-methyl-4-nitropyridine 1-oxide

: 113209-89-5
4-chloro-5-fluoro-2-methylpyridin-1-ium-1-olate

Guidance literature:: With trichlorophosphate; In dichloromethane; 1) RT, 16 h, 2) reflux, 4 h;
DOI:10.1021/jm00128a046

Reference yield:

: 45673-79-8
2‐methyl‐5‐fluoropyridine 1‐oxide

: 113209-89-5
4-chloro-5-fluoro-2-methylpyridin-1-ium-1-olate

Guidance literature:: Multi-step reaction with 2 steps

1: 72 percent / HNO₃, 30percent oleum, conc. H₂SO₄ / 1) 5 deg C to RT, 1 h, 2) steam bath, 2 h

2: 89 percent / POCl₃ / CH₂Cl₂ / 1) RT, 16 h, 2) reflux, 4 h

With sulfuric acid; nitric acid; trichlorophosphate; In dichloromethane;
DOI:10.1021/jm00128a046

Reference yield:

: 31181-53-0
2‐methyl‐5‐fluoropyridine

: 113209-89-5
4-chloro-5-fluoro-2-methylpyridin-1-ium-1-olate

Guidance literature:: Multi-step reaction with 3 steps

1: m-chloroperbenzoic acid / CH₂Cl₂ / 16 h / Ambient temperature

2: 72 percent / HNO₃, 30percent oleum, conc. H₂SO₄ / 1) 5 deg C to RT, 1 h, 2) steam bath, 2 h

3: 89 percent / POCl₃ / CH₂Cl₂ / 1) RT, 16 h, 2) reflux, 4 h

With sulfuric acid; nitric acid; 3-chloro-benzenecarboperoxoic acid; trichlorophosphate; In dichloromethane;
DOI:10.1021/jm00128a046