(2R,3R)-1,7,7-trimethyl-2-(1-naphthyl)bicyclo<2.2.1>hept-3-yl (2R)-2-(4-methoxyphenyl)-2-(3-oxobutyl)-3-oxopropanoate

Base Information

Chemical Name:(2R,3R)-1,7,7-trimethyl-2-(1-naphthyl)bicyclo<2.2.1>hept-3-yl (2R)-2-(4-methoxyphenyl)-2-(3-oxobutyl)-3-oxopropanoate
CAS No.:122172-24-1
Molecular Formula:C₃₄H₃₈O₅
Molecular Weight:526.673
Hs Code.:

Synonyms:(2R,3R)-1,7,7-trimethyl-2-(1-naphthyl)bicyclo<2.2.1>hept-3-yl (2R)-2-(4-methoxyphenyl)-2-(3-oxobutyl)-3-oxopropanoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2R,3R)-1,7,7-trimethyl-2-(1-naphthyl)bicyclo<2.2.1>hept-3-yl (2R)-2-(4-methoxyphenyl)-2-(3-oxobutyl)-3-oxopropanoate

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Technology Process of (2R,3R)-1,7,7-trimethyl-2-(1-naphthyl)bicyclo<2.2.1>hept-3-yl (2R)-2-(4-methoxyphenyl)-2-(3-oxobutyl)-3-oxopropanoate

There total 1 articles about (2R,3R)-1,7,7-trimethyl-2-(1-naphthyl)bicyclo<2.2.1>hept-3-yl (2R)-2-(4-methoxyphenyl)-2-(3-oxobutyl)-3-oxopropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 122172-23-0
(2R,3R)-1,7,7-trimethyl-2-(1-naphthyl)bicyclo<2.2.1>hept-3-yl 2-(4-methoxyphenyl)-3-oxopropanoate

: 78-94-4,25038-87-3
methyl vinyl ketone

: 122172-24-1
(2R,3R)-1,7,7-trimethyl-2-(1-naphthyl)bicyclo<2.2.1>hept-3-yl (2R)-2-(4-methoxyphenyl)-2-(3-oxobutyl)-3-oxopropanoate

: 122211-68-1
(2R,3R)-1,7,7-trimethyl-2-(1-naphthyl)bicyclo<2.2.1>hept-3-yl (2S)-2-(4-methoxyphenyl)-2-(3-oxobutyl)-3-oxopropanoate

Guidance literature:: With potassium carbonate; In various solvent(s); at -50 ℃; for 12h; Product distribution; var. solvents;
DOI:10.1021/jo00277a017

Reference yield: 97.0%

: 122172-24-1
(2R,3R)-1,7,7-trimethyl-2-(1-naphthyl)bicyclo<2.2.1>hept-3-yl (2R)-2-(4-methoxyphenyl)-2-(3-oxobutyl)-3-oxopropanoate

: 540-63-6
ethane-1,2-dithiol

: 122172-25-2
(S)-2-[1,3]Dithiolan-2-yl-2-(4-methoxy-phenyl)-4-(2-methyl-[1,3]dithiolan-2-yl)-butyric acid (1S,2R,3R,4S)-4,7,7-trimethyl-3-naphthalen-1-yl-bicyclo[2.2.1]hept-2-yl ester

Guidance literature:: With zinc trifluoromethanesulfonate; In Petroleum ether; for 1.5h; Ambient temperature;
DOI:10.1021/jo00277a017

Reference yield:

: 122172-24-1
(2R,3R)-1,7,7-trimethyl-2-(1-naphthyl)bicyclo<2.2.1>hept-3-yl (2R)-2-(4-methoxyphenyl)-2-(3-oxobutyl)-3-oxopropanoate

: 122172-32-1
(S)-4-(4-methoxyphenyl)-4-<2-(phenylmethoxy)eth-1-yl>cyclohex-2-en-1-one

Guidance literature:: Multi-step reaction with 8 steps

1: 97 percent / zinc triflate / petroleum ether / 1.5 h / Ambient temperature

2: 90 percent / LiAlH₄ / tetrahydrofuran / 0.5 h

3: 68 percent / pyridinium dichromate, sodium acetate / CH₂Cl₂ / 6 h / 0 °C

4: 1.) phenyllithium / 1.) ether, 0 deg C, 2.) 0 deg C, 1 h

5: 1.) 10percent HCl, 2.) concd HCl / diethyl ether / 15 h

6: 89 percent / NaBH₄ / methanol / 0.08 h / 0 °C

7: 1.) NaH, 2.) TBAI / 1.) DME, 2a.) room temp. to 80 deg C, 2b.) room temp., 10 h

8: 1.) HgO, BF₃*Et₂O, 2.) p-toluenesulfonic acid / 1.) THF, H₂O, 70 min, 2.) reflux, 4 h

With hydrogenchloride; sodium tetrahydroborate; lithium aluminium tetrahydride; dipyridinium dichromate; boron trifluoride diethyl etherate; sodium acetate; tetra-(n-butyl)ammonium iodide; zinc trifluoromethanesulfonate; sodium hydride; toluene-4-sulfonic acid; phenyllithium; mercury(II) oxide; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; Petroleum ether;
DOI:10.1021/jo00277a017