122172-23-0

Upstream product

• 122172-22-9 ethyl 2-(4-methoxyphenyl)-2-formyl acetate 
• 86835-18-9 (4S)-3-exo-(1-naphthyl)-4,7,7-trimethylbicyclo[2.2.1]heptan-2-exo-ol 
• 122172-24-1 (2R,3R)-1,7,7-trimethyl-2-(1-naphthyl)bicyclo<2.2.1>hept-3-yl (2R)-2-(4-methoxyphenyl)-2-(3-oxobutyl)-3-oxopropanoate 
• 122172-25-2 (S)-2-[1,3]Dithiolan-2-yl-2-(4-methoxy-phenyl)-4-(2-methyl-[1,3]dithiolan-2-yl)-butyric acid (1S,2R,3R,4S)-4,7,7-trimethyl-3-naphthalen-1-yl-bicyclo[2.2.1]hept-2-yl ester 
• 14062-18-1 ethyl p-methoxyphenylacetate 
• 104-01-8 4-Methoxyphenylacetic acid 

Downstream Products

• 122172-24-1 (2R,3R)-1,7,7-trimethyl-2-(1-naphthyl)bicyclo<2.2.1>hept-3-yl (2R)-2-(4-methoxyphenyl)-2-(3-oxobutyl)-3-oxopropanoate 
• 122211-68-1 (2R,3R)-1,7,7-trimethyl-2-(1-naphthyl)bicyclo<2.2.1>hept-3-yl (2S)-2-(4-methoxyphenyl)-2-(3-oxobutyl)-3-oxopropanoate 

Relevant academic research and scientific papers

Enantioselective Robinson Annulation: Synthesis of (+)-O-Methyljoubertiamine

The α-formyl ester derived from 2-(1-naphthyl)-3-borneol, as the potassium salt in moist dimethoxymethane, adds to methyl vinyl ketone to give two adducts in a ratio of 95:5.The relative configuration of the major diastereomer has been confirmed by X-ray crystallography.This diastereomer is readily carried on to (+)-O-methyljoubertiamine.The addition of such naphthylbornyl esters to Michael acceptors should constitute a general laboratory-scale procedure for the enantioselective construction of enantiomerically pure quaternary stereogenic centers.