(Z)-pyridin-2-ylmethyl 3-(3-(3-isopropoxy-5-(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)acrylate

Base Information

Chemical Name:(Z)-pyridin-2-ylmethyl 3-(3-(3-isopropoxy-5-(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)acrylate
CAS No.:1333152-11-6
Molecular Formula:C₂₁H₁₉F₃N₄O₃
Molecular Weight:432.402
Hs Code.:

Synonyms:(Z)-pyridin-2-ylmethyl 3-(3-(3-isopropoxy-5-(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)acrylate

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Chemical Property of (Z)-pyridin-2-ylmethyl 3-(3-(3-isopropoxy-5-(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)acrylate

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Technology Process of (Z)-pyridin-2-ylmethyl 3-(3-(3-isopropoxy-5-(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)acrylate

There total 8 articles about (Z)-pyridin-2-ylmethyl 3-(3-(3-isopropoxy-5-(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)acrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 7.3%

: 586-98-1
2-Hydroxymethylpyridine

: 1333153-86-8
(Z)-3-(3-(3-isopropoxy-5-(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)acrylic acid

: 1333152-11-6
(Z)-pyridin-2-ylmethyl 3-(3-(3-isopropoxy-5-(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)acrylate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; In dichloromethane; at 0 ℃; Inert atmosphere;

Reference yield:

: 149793-69-1
3-fluoro-5-trifluoromethyl-benzonitrile

: 1333152-11-6
(Z)-pyridin-2-ylmethyl 3-(3-(3-isopropoxy-5-(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)acrylate

Guidance literature:: Multi-step reaction with 8 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 0 °C

1.2: 14 h / 0 - 60 °C

2.1: thionyl chloride / toluene / 90 °C

3.1: magnesium(II) chloride hexahydrate; sodium monohydrogen sulfide x-hydrate / N,N-dimethyl-formamide / 20 °C

4.1: diethyl ether / 20 °C

5.1: N,N-dimethyl-formamide / 2 h / Reflux

6.1: dichloromethane / 0.5 h / 15 °C

7.1: water; lithium hydroxide / tetrahydrofuran / 20 °C

8.1: N-ethyl-N,N-diisopropylamine; HATU / dichloromethane / 0 °C / Inert atmosphere

With thionyl chloride; sodium monohydrogen sulfide x-hydrate; magnesium(II) chloride hexahydrate; water; sodium hydride; N-ethyl-N,N-diisopropylamine; HATU; lithium hydroxide; In tetrahydrofuran; diethyl ether; dichloromethane; N,N-dimethyl-formamide; toluene; mineral oil;

Reference yield:

: 1333153-38-0
3-isopropoxy-5-(trifluoromethyl)benzamide

: 1333152-11-6
(Z)-pyridin-2-ylmethyl 3-(3-(3-isopropoxy-5-(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)acrylate

Guidance literature:: Multi-step reaction with 7 steps

1: thionyl chloride / toluene / 90 °C

2: magnesium(II) chloride hexahydrate; sodium monohydrogen sulfide x-hydrate / N,N-dimethyl-formamide / 20 °C

3: diethyl ether / 20 °C

4: N,N-dimethyl-formamide / 2 h / Reflux

5: dichloromethane / 0.5 h / 15 °C

6: water; lithium hydroxide / tetrahydrofuran / 20 °C

7: N-ethyl-N,N-diisopropylamine; HATU / dichloromethane / 0 °C / Inert atmosphere

With thionyl chloride; sodium monohydrogen sulfide x-hydrate; magnesium(II) chloride hexahydrate; water; N-ethyl-N,N-diisopropylamine; HATU; lithium hydroxide; In tetrahydrofuran; diethyl ether; dichloromethane; N,N-dimethyl-formamide; toluene;