4-[2-[5-cyano-2-(phenylmethoxy)phenoxy]-3,5-difluoro-6-[3-(4,5-dihydro-1-methyl-1H-imidazol-2-yl)phenoxy]-pyridin-4-yl]oxy-3-methoxybenzoic acid, ethyl ester

Base Information

Chemical Name:4-[2-[5-cyano-2-(phenylmethoxy)phenoxy]-3,5-difluoro-6-[3-(4,5-dihydro-1-methyl-1H-imidazol-2-yl)phenoxy]-pyridin-4-yl]oxy-3-methoxybenzoic acid, ethyl ester
CAS No.:426826-64-4
Molecular Formula:C₃₉H₃₂F₂N₄O₇
Molecular Weight:706.702
Hs Code.:

4-[2-[5-cyano-2-(phenylmethoxy)phenoxy]-3,5-difluoro-6-[3-(4,5-dihydro-1-methyl-1H-imidazol-2-yl)phenoxy]-pyridin-4-yl]oxy-3-methoxybenzoic acid, ethyl ester

Synonyms:4-[2-[5-cyano-2-(phenylmethoxy)phenoxy]-3,5-difluoro-6-[3-(4,5-dihydro-1-methyl-1H-imidazol-2-yl)phenoxy]-pyridin-4-yl]oxy-3-methoxybenzoic acid, ethyl ester

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Chemical Property of 4-[2-[5-cyano-2-(phenylmethoxy)phenoxy]-3,5-difluoro-6-[3-(4,5-dihydro-1-methyl-1H-imidazol-2-yl)phenoxy]-pyridin-4-yl]oxy-3-methoxybenzoic acid, ethyl ester

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Technology Process of 4-[2-[5-cyano-2-(phenylmethoxy)phenoxy]-3,5-difluoro-6-[3-(4,5-dihydro-1-methyl-1H-imidazol-2-yl)phenoxy]-pyridin-4-yl]oxy-3-methoxybenzoic acid, ethyl ester

There total 4 articles about 4-[2-[5-cyano-2-(phenylmethoxy)phenoxy]-3,5-difluoro-6-[3-(4,5-dihydro-1-methyl-1H-imidazol-2-yl)phenoxy]-pyridin-4-yl]oxy-3-methoxybenzoic acid, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 4,5-dihydro-2-(3-hydroxyphenyl)-1-methylimidazole

: 426826-63-3
4-[2-[5-cyano-2-(phenylmethoxy)phenoxy]-3,5,6-trifluoropyridin-4-yl]oxy-3-methoxybenzoic acid, ethyl ester

: 426826-64-4
4-[2-[5-cyano-2-(phenylmethoxy)phenoxy]-3,5-difluoro-6-[3-(4,5-dihydro-1-methyl-1H-imidazol-2-yl)phenoxy]-pyridin-4-yl]oxy-3-methoxybenzoic acid, ethyl ester

Guidance literature:: With caesium carbonate; In dimethyl sulfoxide; at 20 - 35 ℃; for 17h;
DOI:10.1016/S0968-0896(01)00338-8

Reference yield:

: 700-16-3
Pentafluoropyridine

: 426826-64-4
4-[2-[5-cyano-2-(phenylmethoxy)phenoxy]-3,5-difluoro-6-[3-(4,5-dihydro-1-methyl-1H-imidazol-2-yl)phenoxy]-pyridin-4-yl]oxy-3-methoxybenzoic acid, ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 100 percent / cesium carbonate / acetonitrile / 12 h

2: 86 percent / cesium carbonate / acetonitrile / 20 h / 20 - 35 °C

3: 84 percent / cesium carbonate / dimethylsulfoxide / 17 h / 20 - 35 °C

With caesium carbonate; In dimethyl sulfoxide; acetonitrile;
DOI:10.1016/S0968-0896(01)00338-8

Reference yield:

: 617-05-0
ethyl vanillate

: 426826-64-4
4-[2-[5-cyano-2-(phenylmethoxy)phenoxy]-3,5-difluoro-6-[3-(4,5-dihydro-1-methyl-1H-imidazol-2-yl)phenoxy]-pyridin-4-yl]oxy-3-methoxybenzoic acid, ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 100 percent / cesium carbonate / acetonitrile / 12 h

2: 86 percent / cesium carbonate / acetonitrile / 20 h / 20 - 35 °C

3: 84 percent / cesium carbonate / dimethylsulfoxide / 17 h / 20 - 35 °C

With caesium carbonate; In dimethyl sulfoxide; acetonitrile;
DOI:10.1016/S0968-0896(01)00338-8