4-<1-<4-(methoxymethoxy)benzoyl>-1H-indol-3-yl>butyric acid

Base Information

• Chemical Name: 4-<1-<4-(methoxymethoxy)benzoyl>-1H-indol-3-yl>butyric acid
• CAS No.: 148254-72-2
• Molecular Formula: C₂₁H₂₁NO₅
• Molecular Weight: 367.401
• Mol file: 148254-72-2.mol

Synonyms:4-<1-<4-(methoxymethoxy)benzoyl>-1H-indol-3-yl>butyric acid

Chemical Property of 4-<1-<4-(methoxymethoxy)benzoyl>-1H-indol-3-yl>butyric acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-<1-<4-(methoxymethoxy)benzoyl>-1H-indol-3-yl>butyric acid

There total 1 articles about 4-<1-<4-(methoxymethoxy)benzoyl>-1H-indol-3-yl>butyric acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-(methoxymethoxy)benzoic acid (25458-44-0) → 4-<1-<4-(methoxymethoxy)benzoyl>-1H-indol-3-yl>butyric acid (148254-72-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 25 percent / 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride / CH₂Cl₂ / 15 h / Heating

2: 1.) NaH / 1.) DMF, from -45 deg C to 0 deg C, 2.) DMF, -20 deg C, 30 min

With sodium hydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane;

DOI:10.1248/cpb.47.481

Reference yield: 96.9%

benzyl bromide (100-39-0) + 4-<1-<4-(methoxymethoxy)benzoyl>-1H-indol-3-yl>butyric acid (148254-72-2) → benzyl 4-<1-<4-(methoxymethoxy)benzoyl>-1H-indol-3-yl>butyrate (148255-76-9)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 6h;

DOI:10.1248/cpb.47.481

Reference yield:

4-<1-<4-(methoxymethoxy)benzoyl>-1H-indol-3-yl>butyric acid (148254-72-2) → 4-<1-<4-benzoyl>-1H-indol-3-yl>butyric acid

Guidance literature:

Multi-step reaction with 4 steps

1: 96.9 percent / K₂CO₃ / dimethylformamide / 6 h / 20 °C

2: 67.7 percent / TFA / 0.25 h / 25 °C

3: 1.) NaH / 1.) DMF, -40 deg C, 15 min, 2.) DMF, 0 deg C, 4 h

4: 37.3 percent / H₂ / 10 percent Pd/C / tetrahydrofuran / 8 h / 20 °C / 760 Torr

With hydrogen; sodium hydride; potassium carbonate; trifluoroacetic acid; palladium on activated charcoal; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1248/cpb.47.481

upstream raw materials:

4-(methoxymethoxy)benzoic acid

Downstream raw materials:

benzyl 4-<1-<4-(methoxymethoxy)benzoyl>-1H-indol-3-yl>butyrate

benzyl 4-<1-(4-hydroxybenzoyl)-1H-indol-3-yl>butyrate

benzyl 4-<1-<4-benzoyl>-1H-indol-3-yl>butyrate