2-(furan-2-yl)-5-methoxybenzaldehyde

Base Information

• Chemical Name: 2-(furan-2-yl)-5-methoxybenzaldehyde
• CAS No.: 1361252-43-8
• Molecular Formula: C₁₂H₁₀O₃
• Molecular Weight: 202.21
• Mol file: 1361252-43-8.mol

Synonyms:2-(furan-2-yl)-5-methoxybenzaldehyde

Chemical Property of 2-(furan-2-yl)-5-methoxybenzaldehyde

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 2-(furan-2-yl)-5-methoxybenzaldehyde

There total 1 articles about 2-(furan-2-yl)-5-methoxybenzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

fur-2-ylboronic acid (13331-23-2) + 2-bromo-5-methoxy-benzaldehyde (7507-86-0) → 2-(furan-2-yl)-5-methoxybenzaldehyde (1361252-43-8)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; potassium carbonate; In ethanol; toluene; at 100 ℃; for 12h; Sealed tube; Inert atmosphere;

DOI:10.1021/acs.orglett.0c04312

Reference yield: 93.0%

2-(furan-2-yl)-5-methoxybenzaldehyde (1361252-43-8) + acetylenemagnesium bromide (4301-14-8) → 1-(2-(furan-2-yl)-5-methoxyphenyl)prop-2-yn-1-ol

Guidance literature:

In tetrahydrofuran; diethyl ether; at 0 - 20 ℃; for 2.5h; Inert atmosphere;

DOI:10.1021/acs.orglett.0c04312

Reference yield:

2-(furan-2-yl)-5-methoxybenzaldehyde (1361252-43-8) + propargyl bromide (106-96-7) → C15H14O3 (1361252-49-4) + C15H14O3

Guidance literature:

propargyl bromide; With indium; sodium iodide; In N,N-dimethyl-formamide; at 0 - 10 ℃;

2-(furan-2-yl)-5-methoxybenzaldehyde; In N,N-dimethyl-formamide; at 20 ℃;

DOI:10.1016/j.tetlet.2012.01.018

upstream raw materials:

fur-2-ylboronic acid

2-bromo-5-methoxy-benzaldehyde

Downstream raw materials:

C₁₅H₁₄O₃