α-pyrrole ethylbenzene

Base Information

• Chemical Name: α-pyrrole ethylbenzene
• CAS No.: 17289-34-8
• Molecular Formula: C₁₂H₁₃N
• Molecular Weight: 171.242
• Mol file: 17289-34-8.mol

Synonyms:α-pyrrole ethylbenzene

Chemical Property of α-pyrrole ethylbenzene

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of α-pyrrole ethylbenzene

There total 8 articles about α-pyrrole ethylbenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

Butane-1,4-diol (110-63-4) + rac-methylbenzylamine (618-36-0) → α-pyrrole ethylbenzene (17289-34-8)

Guidance literature:

With C₃₀H₂₉BrMnNO₂P₂; potassium carbonate; In neat (no solvent); at 150 ℃; for 24h; Inert atmosphere;

DOI:10.1021/acs.orglett.8b03506

Reference yield: 60.0%

1,4-butenediol (6117-80-2) + rac-methylbenzylamine (618-36-0) → α-pyrrole ethylbenzene (17289-34-8)

Guidance literature:

With [2,2]bipyridinyl; sodium carbonate; nickel dichloride; In toluene; at 130 ℃; for 36h; Inert atmosphere; Schlenk technique;

DOI:10.1021/acs.joc.8b02666

Reference yield: 50.0%

(Z)-4-acetoxy-2-buten-1-yl ethyl carbonate (93500-33-5) + rac-methylbenzylamine (618-36-0) → α-pyrrole ethylbenzene (17289-34-8) + 1-(1-Phenyl-ethyl)-2,5-dihydro-1H-pyrrole

Guidance literature:

Pd(OAc)2 + tppts; In water; acetonitrile; at 45 ℃; for 12h;

DOI:10.1016/S0040-4020(01)80772-9

upstream raw materials:

(Z)-4-acetoxy-2-buten-1-yl ethyl carbonate

rac-methylbenzylamine

L-phenylalanine

methyl 13-hydroperoxyoctadeca-9,11-dienoate

Refernces

• 1、 Borghs, Jannik C.,Lebedev, Yury,Rueping, Magnus,El-Sepelgy, Osama. "Sustainable Manganese-Catalyzed Solvent-Free Synthesis of Pyrroles from 1,4-Diols and Primary Amines". supporting information. p. 70 - 74. Retrieved 2019/01/11.
• 2、 Scalacci, Nicoló,Black, Gary W.,Mattedi, Giulio,Brown, Nicola L.,Turner, Nicholas J.,Castagnolo, Daniele. "Unveiling the Biocatalytic Aromatizing Activity of Monoamine Oxidases MAO-N and 6-HDNO: Development of Chemoenzymatic Cascades for the Synthesis of Pyrroles". . p. 1295 - 1300. Retrieved 2017/08/09.