N-(2-((3-((1H-pyrrolo[2,3-b]pyridin-4-yl)methyl)thioureido)methyl)-3-chlorophenyl)acrylamide hydrochloride

Base Information

Chemical Name:N-(2-((3-((1H-pyrrolo[2,3-b]pyridin-4-yl)methyl)thioureido)methyl)-3-chlorophenyl)acrylamide hydrochloride
CAS No.:1431959-29-3
Molecular Formula:C₁₉H₁₈ClN₅OS*ClH
Molecular Weight:436.365
Hs Code.:

Synonyms:N-(2-((3-((1H-pyrrolo[2,3-b]pyridin-4-yl)methyl)thioureido)methyl)-3-chlorophenyl)acrylamide hydrochloride

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Chemical Property of N-(2-((3-((1H-pyrrolo[2,3-b]pyridin-4-yl)methyl)thioureido)methyl)-3-chlorophenyl)acrylamide hydrochloride

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Technology Process of N-(2-((3-((1H-pyrrolo[2,3-b]pyridin-4-yl)methyl)thioureido)methyl)-3-chlorophenyl)acrylamide hydrochloride

There total 6 articles about N-(2-((3-((1H-pyrrolo[2,3-b]pyridin-4-yl)methyl)thioureido)methyl)-3-chlorophenyl)acrylamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1431959-92-0
C₉H₇N₃S

: 1431960-59-6
C₁₀H₁₁ClN₂O

: 1431959-29-3
N-(2-((3-((1H-pyrrolo[2,3-b]pyridin-4-yl)methyl)thioureido)methyl)-3-chlorophenyl)acrylamide hydrochloride

Guidance literature:: C₉H₇N₃S; C₁₀H₁₁ClN₂O; With triethylamine; In dichloromethane; at 20 ℃;

With hydrogenchloride;

Reference yield:

: 888498-07-5
(1H-pyrrolo[2,3-b]pyridin-4-yl)methanamine

: 1431959-29-3
N-(2-((3-((1H-pyrrolo[2,3-b]pyridin-4-yl)methyl)thioureido)methyl)-3-chlorophenyl)acrylamide hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine; dmap / methanol / 0.5 h / 20 °C / Cooling with ice

1.2: 1.58 h / 20 °C / Cooling with ice

2.1: triethylamine / dichloromethane / 20 °C

With dmap; triethylamine; In methanol; dichloromethane;

Reference yield:

: 6575-11-7
2-amino-6-chlorobenzonitrile

: 1431959-29-3
N-(2-((3-((1H-pyrrolo[2,3-b]pyridin-4-yl)methyl)thioureido)methyl)-3-chlorophenyl)acrylamide hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1: dimethylsulfide borane complex / hexane / 2 h / Reflux; Inert atmosphere

2: potassium acetate / tetrahydrofuran; water / 2 h / 20 °C

3: triethylamine / dichloromethane / 0.17 h / 0 °C

4: trifluoroacetic acid / dichloromethane / 0.5 h / 20 °C

5: triethylamine / dichloromethane / 20 °C

With dimethylsulfide borane complex; potassium acetate; triethylamine; trifluoroacetic acid; In tetrahydrofuran; hexane; dichloromethane; water;