6-benzyloxy-2,3-bis(hydroxymethyl)-1-(2-chloro-4-pyridyl)-7-methoxynaphthalene

Base Information

Chemical Name:6-benzyloxy-2,3-bis(hydroxymethyl)-1-(2-chloro-4-pyridyl)-7-methoxynaphthalene
CAS No.:186461-59-6
Molecular Formula:C₂₅H₂₂ClNO₄
Molecular Weight:435.907
Hs Code.:

Synonyms:6-benzyloxy-2,3-bis(hydroxymethyl)-1-(2-chloro-4-pyridyl)-7-methoxynaphthalene

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Chemical Property of 6-benzyloxy-2,3-bis(hydroxymethyl)-1-(2-chloro-4-pyridyl)-7-methoxynaphthalene

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Technology Process of 6-benzyloxy-2,3-bis(hydroxymethyl)-1-(2-chloro-4-pyridyl)-7-methoxynaphthalene

There total 5 articles about 6-benzyloxy-2,3-bis(hydroxymethyl)-1-(2-chloro-4-pyridyl)-7-methoxynaphthalene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 186462-14-6
6-benzyloxy-2,3-bis(methoxycarbonyl)-1-(2-chloro-4-pyridyl)-7-methoxynaphthalene

: 186461-59-6
6-benzyloxy-2,3-bis(hydroxymethyl)-1-(2-chloro-4-pyridyl)-7-methoxynaphthalene

Guidance literature:: With sodium bis(2-methoxyethoxy)aluminium dihydride; In tetrahydrofuran; toluene; for 1h; Ambient temperature;
DOI:10.1021/jm980314l

Reference yield:

: 101066-61-9
2-chloropyridine-4-carbaldehyde

: 186461-59-6
6-benzyloxy-2,3-bis(hydroxymethyl)-1-(2-chloro-4-pyridyl)-7-methoxynaphthalene

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) n-BuLi / 1.) THF, -70 deg C, 30 min, 2.) THF, -70 deg C, 30 min

2: AcOH / xylene / 2 h / Heating

3: BF₃*Et₂O / acetonitrile / 3 h / Heating

4: 60 percent / Red-Al / tetrahydrofuran; toluene / 1 h / Ambient temperature

With n-butyllithium; boron trifluoride diethyl etherate; acetic acid; sodium bis(2-methoxyethoxy)aluminium dihydride; In tetrahydrofuran; toluene; acetonitrile; xylene;
DOI:10.1021/jm980314l

Reference yield:

: 155044-04-5
6-bromo-3-benzyloxy-4-methoxybenzaldehyde dimethyl acetal

: 186461-59-6
6-benzyloxy-2,3-bis(hydroxymethyl)-1-(2-chloro-4-pyridyl)-7-methoxynaphthalene

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) n-BuLi / 1.) THF, -70 deg C, 30 min, 2.) THF, -70 deg C, 30 min

2: AcOH / xylene / 2 h / Heating

3: BF₃*Et₂O / acetonitrile / 3 h / Heating

4: 60 percent / Red-Al / tetrahydrofuran; toluene / 1 h / Ambient temperature

With n-butyllithium; boron trifluoride diethyl etherate; acetic acid; sodium bis(2-methoxyethoxy)aluminium dihydride; In tetrahydrofuran; toluene; acetonitrile; xylene;
DOI:10.1021/jm980314l