6-benzyloxy-2,3-bis(methoxycarbonyl)-1-(2-chloro-4-pyridyl)-7-methoxynaphthalene

Base Information

• Chemical Name: 6-benzyloxy-2,3-bis(methoxycarbonyl)-1-(2-chloro-4-pyridyl)-7-methoxynaphthalene
• CAS No.: 186462-14-6
• Molecular Formula: C₂₇H₂₂ClNO₆
• Molecular Weight: 491.928
• Mol file: 186462-14-6.mol

Synonyms:6-benzyloxy-2,3-bis(methoxycarbonyl)-1-(2-chloro-4-pyridyl)-7-methoxynaphthalene

Chemical Property of 6-benzyloxy-2,3-bis(methoxycarbonyl)-1-(2-chloro-4-pyridyl)-7-methoxynaphthalene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-benzyloxy-2,3-bis(methoxycarbonyl)-1-(2-chloro-4-pyridyl)-7-methoxynaphthalene

There total 6 articles about 6-benzyloxy-2,3-bis(methoxycarbonyl)-1-(2-chloro-4-pyridyl)-7-methoxynaphthalene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-benzyloxy-1-(2-chloro-pyridin-4-yl)-4-methoxy-11-oxa-tricyclo[6.2.1.02,7]undeca-2,4,6-triene-9,10-dicarboxylic acid dimethyl ester → 6-benzyloxy-2,3-bis(methoxycarbonyl)-1-(2-chloro-4-pyridyl)-7-methoxynaphthalene (186462-14-6)

Guidance literature:

With boron trifluoride diethyl etherate; In acetonitrile; for 3h; Yield given; Heating;

DOI:10.1021/jm980314l

Reference yield:

dimethylfumarate (624-49-7) → 6-benzyloxy-2,3-bis(methoxycarbonyl)-1-(2-chloro-4-pyridyl)-7-methoxynaphthalene (186462-14-6)

Guidance literature:

Multi-step reaction with 2 steps

1: AcOH / xylene / 2 h / Heating

2: BF₃*Et₂O / acetonitrile / 3 h / Heating

With boron trifluoride diethyl etherate; acetic acid; In acetonitrile; xylene;

DOI:10.1021/jm980314l

Reference yield:

2-chloropyridine-4-carbaldehyde (101066-61-9) → 6-benzyloxy-2,3-bis(methoxycarbonyl)-1-(2-chloro-4-pyridyl)-7-methoxynaphthalene (186462-14-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) n-BuLi / 1.) THF, -70 deg C, 30 min, 2.) THF, -70 deg C, 30 min

2: AcOH / xylene / 2 h / Heating

3: BF₃*Et₂O / acetonitrile / 3 h / Heating

With n-butyllithium; boron trifluoride diethyl etherate; acetic acid; In acetonitrile; xylene;

DOI:10.1021/jm980314l

upstream raw materials:

dimethylfumarate

2-chloropyridine-4-carbaldehyde

6-bromo-3-benzyloxy-4-methoxybenzaldehyde dimethyl acetal

(4-benzyloxy-2-dimethoxymethyl-5-methoxy-phenyl)-(2-chloro-pyridin-4-yl)-methanol

Downstream raw materials:

6-benzyloxy-2,3-bis(hydroxymethyl)-1-(2-chloro-4-pyridyl)-7-methoxynaphthalene

6-benzyloxy-2,3-bis(hydroxymethyl)-7-methoxy-1-<2-<1(2H)-phthalazinon-4-(3-pyridyl)-2-yl>-4-pyridyl>-naphthalene

6-benzyloxy-2,3-bis(hydroxymethyl)-1-(2-hydrazino-4-pyridyl)-7-methoxynaphthalene