(R)-piperidine-1,3-dicarboxylic acid 1-benzyl ester 3-tert-butyl ester

Base Information

• Chemical Name: (R)-piperidine-1,3-dicarboxylic acid 1-benzyl ester 3-tert-butyl ester
• CAS No.: 912807-34-2
• Molecular Formula: C₁₈H₂₅NO₄
• Molecular Weight: 319.401
• Mol file: 912807-34-2.mol

Synonyms:(R)-piperidine-1,3-dicarboxylic acid 1-benzyl ester 3-tert-butyl ester

Chemical Property of (R)-piperidine-1,3-dicarboxylic acid 1-benzyl ester 3-tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-piperidine-1,3-dicarboxylic acid 1-benzyl ester 3-tert-butyl ester

There total 1 articles about (R)-piperidine-1,3-dicarboxylic acid 1-benzyl ester 3-tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

isobutene (115-11-7,15220-85-6) + (R)-1-((benzyloxy)carbonyl)piperidine-3-carboxylic acid (160706-62-7) → (R)-piperidine-1,3-dicarboxylic acid 1-benzyl ester 3-tert-butyl ester (912807-34-2)

Guidance literature:

With sulfuric acid; In dichloromethane; at 20 ℃;

DOI:10.1021/jo061268x

Reference yield: 90.0%

(R)-piperidine-1,3-dicarboxylic acid 1-benzyl ester 3-tert-butyl ester (912807-34-2) → (R)-3-N-tert-butoxycarbonylaminopiperidine (912807-35-3)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol; ethyl acetate; for 8h; under 1034.3 Torr;

DOI:10.1021/jo061268x

Reference yield:

(R)-piperidine-1,3-dicarboxylic acid 1-benzyl ester 3-tert-butyl ester (912807-34-2) → (R)-1-[(1R,2R,3S)-3-{(R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy}-2-(4-fluorophenyl)cyclopentylmethyl]piperidine-3-carboxylic acid tert-butyl ester (912807-36-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 90 percent / H₂ / Pd/C / ethanol; ethyl acetate / 8 h / 1034.3 Torr

2.1: i-Pr₂NEt; Ms₂O / toluene / 1.25 h / 38 °C

2.2: iPr₂NEt / toluene / 16 h / Heating

With hydrogen; N-ethyl-N,N-diisopropylamine; Methanesulfonic anhydride; palladium on activated charcoal; In ethanol; ethyl acetate; toluene;

DOI:10.1021/jo061268x

upstream raw materials:

isobutene

(R)-1-((benzyloxy)carbonyl)piperidine-3-carboxylic acid

Downstream raw materials:

(R)-3-N-tert-butoxycarbonylaminopiperidine

(R)-1-[(1R,2R,3S)-3-{(R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy}-2-(4-fluorophenyl)cyclopentylmethyl]piperidine-3-carboxylic acid tert-butyl ester