tert-butyl [1-(4-cyanopyridin-2-yl)-5-(4-methylphenyl)-1H-pyrazol-3-yl]carbamate

Base Information

Chemical Name:tert-butyl [1-(4-cyanopyridin-2-yl)-5-(4-methylphenyl)-1H-pyrazol-3-yl]carbamate
CAS No.:1613412-34-2
Molecular Formula:C₂₁H₂₁N₅O₂
Molecular Weight:375.43
Hs Code.:

Synonyms:tert-butyl [1-(4-cyanopyridin-2-yl)-5-(4-methylphenyl)-1H-pyrazol-3-yl]carbamate

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Chemical Property of tert-butyl [1-(4-cyanopyridin-2-yl)-5-(4-methylphenyl)-1H-pyrazol-3-yl]carbamate

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Technology Process of tert-butyl [1-(4-cyanopyridin-2-yl)-5-(4-methylphenyl)-1H-pyrazol-3-yl]carbamate

There total 7 articles about tert-butyl [1-(4-cyanopyridin-2-yl)-5-(4-methylphenyl)-1H-pyrazol-3-yl]carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 1613412-33-1
1-(4-cyanopyridin-2-yl)-5-(4-methylphenyl)-1H-pyrazole-3-carboxylic acid

: 75-65-0
tert-butyl alcohol

: 1613412-34-2
tert-butyl [1-(4-cyanopyridin-2-yl)-5-(4-methylphenyl)-1H-pyrazol-3-yl]carbamate

Guidance literature:: 1-(4-cyanopyridin-2-yl)-5-(4-methylphenyl)-1H-pyrazole-3-carboxylic acid; With triethylamine; isobutyl chloroformate; In tetrahydrofuran; at 20 ℃; for 1h;

With sodium azide; In tetrahydrofuran; water; for 1h;

tert-butyl alcohol; at 75 ℃; for 4h;

Reference yield:

: 913839-68-6
2-hydrazinylpyridine-4-carbonitrile

: 1613412-34-2
tert-butyl [1-(4-cyanopyridin-2-yl)-5-(4-methylphenyl)-1H-pyrazol-3-yl]carbamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogenchloride / ethyl acetate / 0.5 h / 20 °C

2.1: acetic acid / 0.5 h / 100 °C

3.1: sodium hydroxide; water / tetrahydrofuran; N,N-dimethyl-formamide / 65 °C

4.1: isobutyl chloroformate; triethylamine / tetrahydrofuran / 1 h / 20 °C

4.2: 1 h

4.3: 4 h / 75 °C

With hydrogenchloride; water; acetic acid; triethylamine; sodium hydroxide; isobutyl chloroformate; In tetrahydrofuran; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 33252-30-1
2-chloro-4-pyridinenitrile

: 1613412-34-2
tert-butyl [1-(4-cyanopyridin-2-yl)-5-(4-methylphenyl)-1H-pyrazol-3-yl]carbamate

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrazine hydrate / butan-1-ol; tetrahydrofuran / 60 °C

2.1: hydrogenchloride / ethyl acetate / 0.5 h / 20 °C

3.1: acetic acid / 0.5 h / 100 °C

4.1: sodium hydroxide; water / tetrahydrofuran; N,N-dimethyl-formamide / 65 °C

5.1: isobutyl chloroformate; triethylamine / tetrahydrofuran / 1 h / 20 °C

5.2: 1 h

5.3: 4 h / 75 °C

With hydrogenchloride; water; hydrazine hydrate; acetic acid; triethylamine; sodium hydroxide; isobutyl chloroformate; In tetrahydrofuran; ethyl acetate; N,N-dimethyl-formamide; butan-1-ol;