methyl 5-(3,3-dimethylbut-1-ynyl)-3-(4-oxocyclohexylamino)thiophene-2-carboxylate

Base Information

Chemical Name:methyl 5-(3,3-dimethylbut-1-ynyl)-3-(4-oxocyclohexylamino)thiophene-2-carboxylate
CAS No.:1263101-15-0
Molecular Formula:C₁₈H₂₃NO₃S
Molecular Weight:333.452
Hs Code.:

Synonyms:methyl 5-(3,3-dimethylbut-1-ynyl)-3-(4-oxocyclohexylamino)thiophene-2-carboxylate

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Chemical Property of methyl 5-(3,3-dimethylbut-1-ynyl)-3-(4-oxocyclohexylamino)thiophene-2-carboxylate

Chemical Property:

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Technology Process of methyl 5-(3,3-dimethylbut-1-ynyl)-3-(4-oxocyclohexylamino)thiophene-2-carboxylate

There total 10 articles about methyl 5-(3,3-dimethylbut-1-ynyl)-3-(4-oxocyclohexylamino)thiophene-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 1263101-80-9
5-(3,3-dimethyl-but-1-ynyl)-3-(1,4-dioxa-spiro[4.5]dec-8-ylamino)-thiophene-2-carboxylic acid methyl ester

: 1263101-15-0
methyl 5-(3,3-dimethylbut-1-ynyl)-3-(4-oxocyclohexylamino)thiophene-2-carboxylate

Guidance literature:: With hydrogenchloride; In tetrahydrofuran; water; at 40 ℃; Inert atmosphere;

Reference yield:

: 917-92-0
3,3-Dimethylbut-1-yne

: 1263101-15-0
methyl 5-(3,3-dimethylbut-1-ynyl)-3-(4-oxocyclohexylamino)thiophene-2-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; copper(l) iodide / N,N-dimethyl-formamide / 0.17 h / Inert atmosphere

1.2: 60 °C

2.1: trifluoroacetic acid / dichloromethane / 20 °C

3.1: sodium tris(acetoxy)borohydride; acetic acid / toluene / 20 °C / Inert atmosphere

4.1: hydrogenchloride / tetrahydrofuran; water / 40 °C / Inert atmosphere

With hydrogenchloride; sodium tris(acetoxy)borohydride; acetic acid; triethylamine; trifluoroacetic acid; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; copper(l) iodide; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; toluene;

Reference yield:

: 946604-99-5
methyl 5-bromo-3-((tert-butoxycarbonyl)amino)thiophene-2-carboxylate

: 1263101-15-0
methyl 5-(3,3-dimethylbut-1-ynyl)-3-(4-oxocyclohexylamino)thiophene-2-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; copper(l) iodide / N,N-dimethyl-formamide / 0.17 h / Inert atmosphere

1.2: 60 °C

2.1: trifluoroacetic acid / dichloromethane / 20 °C

3.1: sodium tris(acetoxy)borohydride; acetic acid / toluene / 20 °C / Inert atmosphere

4.1: hydrogenchloride / tetrahydrofuran; water / 40 °C / Inert atmosphere

With hydrogenchloride; sodium tris(acetoxy)borohydride; acetic acid; triethylamine; trifluoroacetic acid; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; copper(l) iodide; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; toluene;