ethyl 2-methyl-2-{2-methyl-4-[(4-methyl-2-(4-trifluoromethylphenyl)thiazol-5-yl)methylthio]phenoxy}propanoate

Base Information

• Chemical Name: ethyl 2-methyl-2-{2-methyl-4-[(4-methyl-2-(4-trifluoromethylphenyl)thiazol-5-yl)methylthio]phenoxy}propanoate
• CAS No.: 1268500-86-2
• Molecular Formula: C₂₅H₂₆F₃NO₃S₂
• Molecular Weight: 509.614

Synonyms:ethyl 2-methyl-2-{2-methyl-4-[(4-methyl-2-(4-trifluoromethylphenyl)thiazol-5-yl)methylthio]phenoxy}propanoate

Chemical Property of ethyl 2-methyl-2-{2-methyl-4-[(4-methyl-2-(4-trifluoromethylphenyl)thiazol-5-yl)methylthio]phenoxy}propanoate

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Technology Process of ethyl 2-methyl-2-{2-methyl-4-[(4-methyl-2-(4-trifluoromethylphenyl)thiazol-5-yl)methylthio]phenoxy}propanoate

There total 2 articles about ethyl 2-methyl-2-{2-methyl-4-[(4-methyl-2-(4-trifluoromethylphenyl)thiazol-5-yl)methylthio]phenoxy}propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

ethyl 2-bromoisobutyrate (600-00-0) + 4-{{2-[4-(trifluoromethyl)phenyl]-4-methylthiazol-5-yl}methylthio}-2-methylphenol (636589-63-4) → ethyl 2-methyl-2-{2-methyl-4-[(4-methyl-2-(4-trifluoromethylphenyl)thiazol-5-yl)methylthio]phenoxy}propanoate (1268500-86-2)

Guidance literature:

With caesium carbonate; In acetonitrile; at 20 ℃; Inert atmosphere;

DOI:10.1002/ardp.201000189

Reference yield:

4-mercapto-2-methylphenol (32281-01-9) → ethyl 2-methyl-2-{2-methyl-4-[(4-methyl-2-(4-trifluoromethylphenyl)thiazol-5-yl)methylthio]phenoxy}propanoate (1268500-86-2)

Guidance literature:

Multi-step reaction with 2 steps

1: caesium carbonate / acetonitrile / 4 h / 20 °C / Inert atmosphere

2: caesium carbonate / acetonitrile / 20 °C / Inert atmosphere

With caesium carbonate; In acetonitrile;

DOI:10.1002/ardp.201000189

Reference yield: 45.0%

ethyl 2-methyl-2-{2-methyl-4-[(4-methyl-2-(4-trifluoromethylphenyl)thiazol-5-yl)methylthio]phenoxy}propanoate (1268500-86-2) → 2-methyl-2-{2-methyl-4-[(4-methyl-2-(4-trifluoromethylphenyl)thiazol-5-yl)methylthio]phenoxy}propanoic acid (1026868-55-2)

Guidance literature:

With potassium tert-butylate; water; In tetrahydrofuran; for 24h; Reflux;

DOI:10.1002/ardp.201000189

upstream raw materials:

ethyl 2-bromoisobutyrate

4-{{2-[4-(trifluoromethyl)phenyl]-4-methylthiazol-5-yl}methylthio}-2-methylphenol

4-mercapto-2-methylphenol

Downstream raw materials:

2-methyl-2-{2-methyl-4-[(4-methyl-2-(4-trifluoromethylphenyl)thiazol-5-yl)methylthio]phenoxy}propanoic acid

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