4-(4-chlorophenyl)-1-(3,3-diphenylpropyl)-4-fluoropiperidine hydrochloride

Base Information

Chemical Name:4-(4-chlorophenyl)-1-(3,3-diphenylpropyl)-4-fluoropiperidine hydrochloride
CAS No.:1345609-57-5
Molecular Formula:C₂₆H₂₇ClFN*ClH
Molecular Weight:444.419
Hs Code.:

Synonyms:4-(4-chlorophenyl)-1-(3,3-diphenylpropyl)-4-fluoropiperidine hydrochloride

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Chemical Property of 4-(4-chlorophenyl)-1-(3,3-diphenylpropyl)-4-fluoropiperidine hydrochloride

Chemical Property:

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Technology Process of 4-(4-chlorophenyl)-1-(3,3-diphenylpropyl)-4-fluoropiperidine hydrochloride

There total 5 articles about 4-(4-chlorophenyl)-1-(3,3-diphenylpropyl)-4-fluoropiperidine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

: 1345610-11-8
4-(4-chlorophenyl)-1-(3,3-diphenylpropyl)-4-fluoropiperidine

: 1345609-57-5
4-(4-chlorophenyl)-1-(3,3-diphenylpropyl)-4-fluoropiperidine hydrochloride

Guidance literature:: With hydrogenchloride; In methanol;

Reference yield:

: 39512-49-7
4-(4-chlorophenyl)-4-hydroxypiperidine

: 1345609-57-5
4-(4-chlorophenyl)-1-(3,3-diphenylpropyl)-4-fluoropiperidine hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1: N-ethyl-N,N-diisopropylamine / dichloromethane / 6 h / 20 °C

2: diethylamino-sulfur trifluoride / dichloromethane / 14 h / 20 °C / Cooling with ice/salt bath

3: hydrogenchloride / methanol / 64 h / 20 °C

4: potassium carbonate / N,N-dimethyl-formamide / 14 h / 80 °C

5: hydrogenchloride / methanol

With hydrogenchloride; diethylamino-sulfur trifluoride; potassium carbonate; N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1345610-08-3
tert-butyl 4-(4-chlorophenyl)-4-fluoropiperidine-1-carboxylate

: 1345609-57-5
4-(4-chlorophenyl)-1-(3,3-diphenylpropyl)-4-fluoropiperidine hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogenchloride / methanol / 64 h / 20 °C

2: potassium carbonate / N,N-dimethyl-formamide / 14 h / 80 °C

3: hydrogenchloride / methanol

With hydrogenchloride; potassium carbonate; In methanol; N,N-dimethyl-formamide;