Thiocarbonic acid S-((2S,3S)-3-{2-[(Z)-methoxyimino]-2-[2-(trityl-amino)-thiazol-4-yl]-acetylamino}-4-oxo-azetidin-2-ylmethyl) ester O-(4-nitro-phenyl) ester

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Chemical Name:Thiocarbonic acid S-((2S,3S)-3-{2-[(Z)-methoxyimino]-2-[2-(trityl-amino)-thiazol-4-yl]-acetylamino}-4-oxo-azetidin-2-ylmethyl) ester O-(4-nitro-phenyl) ester
CAS No.:176748-48-4
Molecular Formula:C₃₆H₃₀N₆O₇S₂
Molecular Weight:722.802
Hs Code.:

Thiocarbonic acid S-((2S,3S)-3-{2-[(Z)-methoxyimino]-2-[2-(trityl-amino)-thiazol-4-yl]-acetylamino}-4-oxo-azetidin-2-ylmethyl) ester O-(4-nitro-phenyl) ester

Synonyms:Thiocarbonic acid S-((2S,3S)-3-{2-[(Z)-methoxyimino]-2-[2-(trityl-amino)-thiazol-4-yl]-acetylamino}-4-oxo-azetidin-2-ylmethyl) ester O-(4-nitro-phenyl) ester

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Chemical Property of Thiocarbonic acid S-((2S,3S)-3-{2-[(Z)-methoxyimino]-2-[2-(trityl-amino)-thiazol-4-yl]-acetylamino}-4-oxo-azetidin-2-ylmethyl) ester O-(4-nitro-phenyl) ester

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Technology Process of Thiocarbonic acid S-((2S,3S)-3-{2-[(Z)-methoxyimino]-2-[2-(trityl-amino)-thiazol-4-yl]-acetylamino}-4-oxo-azetidin-2-ylmethyl) ester O-(4-nitro-phenyl) ester

There total 4 articles about Thiocarbonic acid S-((2S,3S)-3-{2-[(Z)-methoxyimino]-2-[2-(trityl-amino)-thiazol-4-yl]-acetylamino}-4-oxo-azetidin-2-ylmethyl) ester O-(4-nitro-phenyl) ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 7693-46-1
4-Nitrophenyl chloroformate

: 176894-32-9
N-((2S,3S)-2-Mercaptomethyl-4-oxo-azetidin-3-yl)-2-[(Z)-methoxyimino]-2-[2-(trityl-amino)-thiazol-4-yl]-acetamide

: 176748-48-4
Thiocarbonic acid S-((2S,3S)-3-{2-[(Z)-methoxyimino]-2-[2-(trityl-amino)-thiazol-4-yl]-acetylamino}-4-oxo-azetidin-2-ylmethyl) ester O-(4-nitro-phenyl) ester

Guidance literature:: In dichloromethane; N,N-dimethyl-formamide; at 0 ℃; for 0.25h;

Reference yield:

: 176894-29-4
N-((2S,3S)-2-Hydroxymethyl-4-oxo-azetidin-3-yl)-2-[(Z)-methoxyimino]-2-[2-(trityl-amino)-thiazol-4-yl]-acetamide

: 176748-48-4
Thiocarbonic acid S-((2S,3S)-3-{2-[(Z)-methoxyimino]-2-[2-(trityl-amino)-thiazol-4-yl]-acetylamino}-4-oxo-azetidin-2-ylmethyl) ester O-(4-nitro-phenyl) ester

Guidance literature:: Multi-step reaction with 4 steps

1: 93 percent / pyridine / 2 h / 0 °C

2: 80 percent / NaI / butan-2-one / 2.5 h / Heating

3: 80 percent / NaSH*H₂O / dimethylformamide / 0.25 h / 0 °C

4: 64 percent / CH₂Cl₂; dimethylformamide / 0.25 h / 0 °C

With pyridine; sodium hydrogensulfide; sodium iodide; In dichloromethane; N,N-dimethyl-formamide; butanone;

Reference yield:

: 94105-04-1
N-((2S,3S)-2-Iodomethyl-4-oxo-azetidin-3-yl)-2-[(Z)-methoxyimino]-2-[2-(trityl-amino)-thiazol-4-yl]-acetamide

: 176748-48-4
Thiocarbonic acid S-((2S,3S)-3-{2-[(Z)-methoxyimino]-2-[2-(trityl-amino)-thiazol-4-yl]-acetylamino}-4-oxo-azetidin-2-ylmethyl) ester O-(4-nitro-phenyl) ester

Guidance literature:: Multi-step reaction with 2 steps

1: 80 percent / NaSH*H₂O / dimethylformamide / 0.25 h / 0 °C

2: 64 percent / CH₂Cl₂; dimethylformamide / 0.25 h / 0 °C

With sodium hydrogensulfide; In dichloromethane; N,N-dimethyl-formamide;