3-({1-[(tert-butoxy)carbonyl]piperidin-4-yl}(ethyl)amino)-5-chloro-2-methylbenzoic acid

Base Information

Chemical Name:3-({1-[(tert-butoxy)carbonyl]piperidin-4-yl}(ethyl)amino)-5-chloro-2-methylbenzoic acid
CAS No.:1403596-37-1
Molecular Formula:C₂₀H₂₉ClN₂O₄
Molecular Weight:396.914
Hs Code.:

Synonyms:3-({1-[(tert-butoxy)carbonyl]piperidin-4-yl}(ethyl)amino)-5-chloro-2-methylbenzoic acid

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Chemical Property of 3-({1-[(tert-butoxy)carbonyl]piperidin-4-yl}(ethyl)amino)-5-chloro-2-methylbenzoic acid

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Technology Process of 3-({1-[(tert-butoxy)carbonyl]piperidin-4-yl}(ethyl)amino)-5-chloro-2-methylbenzoic acid

There total 4 articles about 3-({1-[(tert-butoxy)carbonyl]piperidin-4-yl}(ethyl)amino)-5-chloro-2-methylbenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1403595-32-3
tert-butyl 4-((5-chloro-3-(methoxycarbonyl)-2-methylphenyl)-(ethyl)-amino)piperidine-1-carboxylate

: 1403596-37-1
3-({1-[(tert-butoxy)carbonyl]piperidin-4-yl}(ethyl)amino)-5-chloro-2-methylbenzoic acid

Guidance literature:: tert-butyl 4-((5-chloro-3-(methoxycarbonyl)-2-methylphenyl)-(ethyl)-amino)piperidine-1-carboxylate; With water; lithium hydroxide; In tetrahydrofuran; at 20 ℃; for 24h;

With sodium hydroxide; In tetrahydrofuran; at 20 - 45 ℃; for 49h;

With hydrogenchloride; In tetrahydrofuran; water; pH=2 - 3;

Reference yield:

: 294190-18-4
methyl 3-amino-5-chloro-2-methylbenzoate

: 1403596-37-1
3-({1-[(tert-butoxy)carbonyl]piperidin-4-yl}(ethyl)amino)-5-chloro-2-methylbenzoic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: acetic acid; sodium tris(acetoxy)borohydride / dichloromethane / 18 h / 23 °C

2.1: acetic acid / 1,2-dichloro-ethane / 0.08 h / 20 °C / Inert atmosphere

2.2: 22.5 h / 20 °C

3.1: water; lithium hydroxide / tetrahydrofuran / 24 h / 20 °C

3.2: 49 h / 20 - 45 °C

3.3: pH 2 - 3

With water; sodium tris(acetoxy)borohydride; acetic acid; lithium hydroxide; In tetrahydrofuran; dichloromethane; 1,2-dichloro-ethane;

Reference yield:

: 79099-07-3
N-tert-butyloxycarbonylpiperidin-4-one

: 1403596-37-1
3-({1-[(tert-butoxy)carbonyl]piperidin-4-yl}(ethyl)amino)-5-chloro-2-methylbenzoic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: acetic acid; sodium tris(acetoxy)borohydride / dichloromethane / 18 h / 23 °C

2.1: acetic acid / 1,2-dichloro-ethane / 0.08 h / 20 °C / Inert atmosphere

2.2: 22.5 h / 20 °C

3.1: water; lithium hydroxide / tetrahydrofuran / 24 h / 20 °C

3.2: 49 h / 20 - 45 °C

3.3: pH 2 - 3

With water; sodium tris(acetoxy)borohydride; acetic acid; lithium hydroxide; In tetrahydrofuran; dichloromethane; 1,2-dichloro-ethane;